ReviewWorld journal of gastroenterology2016
Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness.
Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- A liver function test pathway significantly increases the early detection of chronic liver disease and cirrhosis.Hepatology communications · 2026Article
- Evaluation of Prognosis in Cirrhotic Patients with Esophageal Variceal Bleeding Using Non-Invasive Scores.Medicina (Kaunas, Lithuania) · 2025Article
- Liver Stiffness Values to Predict Occurrence and Recurrence of Hepatocellular Carcinoma.Life (Basel, Switzerland) · 2024Review
- Noninvasive Fibrosis Assessment in Chronic Hepatitis C Infection: An Update.Journal of clinical and translational hepatology · 2023Review
- Enhanced liver fibrosis score as a noninvasive biomarker in hepatitis C virus patients after direct-acting antiviral agents.Frontiers in pharmacology · 2022Article
- Potential role of noninvasive biomarkers during liver fibrosis.World journal of hepatology · 2021Review
- Evaluation of Non-invasive Fibrosis Markers in Predicting Esophageal Variceal Bleeding.Clinical endoscopy · 2021Article
- Growth differentiation factor 15: an emerging diagnostic biomarker of liver fibrosis in chronic hepatitis C patients.Egyptian liver journal · 2021Article
- Evaluation of Rabbits Liver Fibrosis Using Gd-DTPA-BMA of Dynamic Contrast-Enhanced Magnetic Resonance Imaging.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Relationship of FIB-4 index with transient elastography in chronic hepatitis C patients having APRI ≥ 0.5 - ≤2 in a resource-limited setting in Pakistan.Journal of family medicine and primary care · 2020Article
- Liver fibrosis is a major risk factor for liver regeneration: A comparison between healthy and fibrotic liver.Medicine · 2020Observational
- Significant decrease in liver stiffness detected by two dimensional shear-wave elastography after treatment with direct-acting antiviral agents in patients with chronic Hepatitis C.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Application of acoustic radiation force impulse elastography combined with serum markers in Child-Pugh grading.Clinics (Sao Paulo, Brazil) · 2020Article
- Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection.Journal of clinical medicine · 2019Article
- Use of serum biomarkers in staging of canine hepatic fibrosis.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Prediction and Staging of Hepatic Fibrosis in Children with Hepatitis C Virus: A Machine Learning Approach.Healthcare informatics research · 2019Article
- Recent research trends and updates on nonalcoholic fatty liver disease.Clinical and molecular hepatology · 2019Review
- Magnetic resonance elastography: basic principles, technique, and clinical applications in the liver.Diagnostic and interventional radiology (Ankara, Turkey) · 2018Review
- Clinical epidemiology of chronic viral hepatitis B: A Tuscany real-word large-scale cohort study.World journal of hepatology · 2018Article
- Quantitative and noninvasive assessment of chronic liver diseases using two-dimensional shear wave elastography.World journal of gastroenterology · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assessment of the fibrotic evolution of chronic hepatitis has always been a challenge for the clinical hepatologist. Over the past decade, various non-invasive methods have been proposed to detect the presence of fibrosis, including the elastometric measure of stiffness, panels of clinical and biochemical parameters, and combinations of both methods. The aim of this review is to analyse the most recent data on non-invasive techniques for the evaluation of hepatic fibrosis with particular attention to cost-effectiveness. We searched for relevant studies published in English using the PubMed database from 2009 to the present. A large number of studies have suggested that elastography and serum markers are useful techniques for diagnosing severe fibrosis and cirrhosis and for excluding significant fibrosis in hepatitis C virus patients. In addition, hepatic stiffness may also help to prognosticate treatment response to antiviral therapy. It has also been shown that magnetic resonance elastography has a high accuracy for staging and differentiating liver fibrosis. Finally, studies have shown that non-invasive methods are becoming increasingly precise in either positively identifying or excluding liver fibrosis, thus reducing the need for liver biopsy. However, both serum markers and transient elastography still have "grey area" values of lower accuracy. In this case, liver biopsy is still required to properly assess liver fibrosis. Recently, the guidelines produced by the World Health Organization have suggested that the AST-to-platelet ratio index or FIB-4 test could be utilised for the evaluation of liver fibrosis rather than other, more expensive non-invasive tests, such as elastography or FibroTest.
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