Evidence map›Paper›PMID 26819507›Full record

ReviewWorld journal of gastroenterology2016

Vertically acquired hepatitis C virus infection: Correlates of transmission and disease progression.

Pier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Update on Pediatric Hepatitis C Infection.Current gastroenterology reports · 2025
    Review
  3. Review
  4. Review
  5. Overall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  6. Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Perinatal transmission of hepatitis C virus: an update.Archives of medical science : AMS · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pier-Angelo TovoPier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino, Department of Pediatrics, School of Medicine, University of Torino, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Carmelina CalitriPier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino, Department of Pediatrics, School of Medicine, University of Torino, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Carlo ScolfaroPier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino, Department of Pediatrics, School of Medicine, University of Torino, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Clara GabianoPier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino, Department of Pediatrics, School of Medicine, University of Torino, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Silvia GarazzinoPier-Angelo Tovo, Carmelina Calitri, Carlo Scolfaro, Clara Gabiano, Silvia Garazzino, Department of Pediatrics, School of Medicine, University of Torino, Ospedale Infantile Regina Margherita, Città della Salute e della Scienza, 10126 Torino, Italy.
Ospedale Regina Margherita · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The worldwide prevalence of hepatitis C virus (HCV) infection in children is 0.05%-0.4% in developed countries and 2%-5% in resource-limited settings, where inadequately tested blood products or un-sterile medical injections still remain important routes of infection. After the screening of blood donors, mother-to-child transmission (MTCT) of HCV has become the leading cause of pediatric infection, at a rate of 5%. Maternal HIV co-infection is a significant risk factor for MTCT and anti-HIV therapy during pregnancy seemingly can reduce the transmission rate of both viruses. Conversely, a high maternal viral load is an important, but not preventable risk factor, because at present no anti-HCV treatment can be administered to pregnant women to block viral replication. Caution is needed in adopting obstetric procedures, such as amniocentesis or internal fetal monitoring, that can favor fetal exposure to HCV contaminated maternal blood, though evidence is lacking on the real risk of single obstetric practices. Mode of delivery and type of feeding do not represent significant risk factors for MTCT. Therefore, there is no reason to offer elective caesarean section or discourage breast-feeding to HCV infected parturients. Information on the natural history of vertical HCV infection is limited. The primary infection is asymptomatic in infants. At least one quarter of infected children shows a spontaneous viral clearance (SVC) that usually occurs within 6 years of life. IL-28B polymorphims and genotype 3 infection have been associated with greater chances of SVC. In general, HCV progression is mild or moderate in children with chronic infection who grow regularly, though cases with marked liver fibrosis or hepatic failure have been described. Non-organ specific autoantibodies and cryoglobulins are frequently found in children with chronic infection, but autoimmune diseases or HCV associated extrahepatic manifestations are rare.

Indexed as

Infectious Disease Transmission, VerticalAge FactorsAntiviral AgentsCoinfectionDisease ProgressionFemaleHepacivirusHepatitis CHumansPregnancyRemission InductionRisk FactorsTreatment OutcomeViral LoadAntiviral AgentsDisease progressionHepatitis C virusPediatricsRisk factorsSpontaneous viral clearanceVertical transmission

Identifiers

PMID26819507
PMCPMC4721973
OpenAlexW2417140367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.