Evidence map›Paper›PMID 26819339›Full record

ArticleSexually transmitted infections2016

Prevalence of reproductive tract infections and the predictive value of girls' symptom-based reporting: findings from a cross-sectional survey in rural western Kenya.

Emily Kerubo, Kayla F Laserson, Newton Otecko, Collins Odhiambo, Linda Mason, Elizabeth Nyothach, Kelvin O Oruko, Ashley Bauman, John Vulule, Clement Zeh and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Sexually transmitted infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  10. Prevalence of genitalJournal of public health in Africa · 2022
    Article
  11. Article
  12. Nanophotonic Sialidase Immunoassay for Bacterial Vaginosis Diagnosis.ACS pharmacology & translational science · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Emily KeruboCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Kayla F LasersonDivision of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention (CDC), Atlanta, USA.
Newton OteckoCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Collins OdhiamboCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Linda MasonDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Elizabeth NyothachCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Kelvin O OrukoCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Ashley BaumanDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
John VululeCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya.
Clement ZehDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Kisumu, Kenya.
Penelope A Phillips-HowardCenter for Global Health Research, Kenya Medical Research Institute (KEMRI) Kisumu, Kisumu, Kenya Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0003-1018-116X
Kenya Medical Research Institute · KELiverpool School of Tropical Medicine · GBCenters for Disease Control and Prevention · KECenters for Disease Control and Prevention · US

Funding

Medical Research Council G1100677
6 · The paper itself

Abstract

objectivesReproductive tract infections (RTIs), including sexually acquired, among adolescent girls is a public health concern, but few studies have measured prevalence in low-middle-income countries. The objective of this study was to examine prevalence in rural schoolgirls in Kenya against their reported symptoms.

methodsIn 2013, a survey was conducted in 542 adolescent schoolgirls aged 14-17 years who were enrolled in a menstrual feasibility study. Vaginal self-swabbing was conducted after girls were interviewed face-to-face by trained nurses on symptoms. The prevalence of girls with symptoms and laboratory-confirmed infections, and the sensitivity, specificity, positive and negative predictive values of symptoms compared with laboratory results, were calculated.

resultsOf 515 girls agreeing to self-swab, 510 answered symptom questions. A quarter (24%) reported one or more symptoms; most commonly vaginal discharge (11%), pain (9%) or itching (4%). Laboratory tests confirmed 28% of girls had one or more RTI. Prevalence rose with age; among girls aged 16-17 years, 33% had infections. Bacterial vaginosis was the most common (18%), followed by Candida albicans (9%), Chlamydia trachomatis (3%), Trichomonas vaginalis (3%) and Neisseria gonorrhoeae (1%). Reported symptoms had a low sensitivity and positive predictive value. Three-quarters of girls with bacterial vaginosis and C. albicans, and 50% with T. vaginalis were asymptomatic.

conclusionsThere is a high prevalence of adolescent schoolgirls with RTI in rural Kenya. Public efforts are required to identify and treat infections among girls to reduce longer-term sequelae but poor reliability of symptom reporting minimises utility of symptom-based diagnosis in this population. TRIAL REGISTRATION NUMBER: ISRCTN17486946.

Indexed as

Women's HealthAdolescentChlamydia InfectionsCross-Sectional StudiesFeasibility StudiesFemaleGonorrheaHealth Knowledge, Attitudes, PracticeHumansKenyaPrevalenceReproducibility of ResultsReproductive Tract InfectionsRural HealthRural PopulationSexual BehaviorADOLESCENTAFRICADIAGNOSISREPRODUCTIVE HEALTHSEXUAL HEALTH

Identifiers

PMID26819339
PMCPMC4893088
OpenAlexW2262107413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.