Evidence map›Paper›PMID 26819283›Full record

ArticleThe international journal of neuropsychopharmacology2016

Maternal Immune Activation Disrupts Dopamine System in the Offspring.

Antonio Luchicchi, Salvatore Lecca, Miriam Melis, Marta De Felice, Francesca Cadeddu, Roberto Frau, Anna Lisa Muntoni, Paola Fadda, Paola Devoto, Marco Pistis

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In one paragraph

Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
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  8. Pioglitazone attenuates behavioral and electrophysiological dysfunctions induced by two-hit model of schizophrenia in adult rodent offspring.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024
    Article
  9. [Research progress on the mechanism of the impact of maternal childhood trauma on intergenerational transmission].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  10. Review
  11. Maternal Immune Activation Induces Cortical Catecholaminergic Hypofunction and Cognitive Impairments in Offspring.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonio LuchicchiDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Salvatore LeccaDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Miriam MelisDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Marta De FeliceDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Francesca CadedduDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Roberto FrauDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Anna Lisa MuntoniDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Paola FaddaDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Paola DevotoDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France.
Marco PistisDivision of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy (Drs Luchicchi, Lecca, Melis, Ms De Felice, Drs Cadeddu, Frau, Fadda, Devoto, and Pistis); Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Italy (Drs Muntoni and Pistis).Present address (A.L.): Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, Amsterdam, Netherlands.Present address (S.L.): Institut du Fer à Moulin, 75005, Paris, France; Inserm, UMR-S 839, 75005, Paris, France. mpistis@unica.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn utero exposure to maternal viral infections is associated with a higher incidence of psychiatric disorders with a supposed neurodevelopmental origin, including schizophrenia. Hence, immune response factors exert a negative impact on brain maturation that predisposes the offspring to the emergence of pathological phenotypes later in life. Although ventral tegmental area dopamine neurons and their target regions play essential roles in the pathophysiology of psychoses, it remains to be fully elucidated how dopamine activity and functionality are disrupted in maternal immune activation models of schizophrenia.

methodsHere, we used an immune-mediated neurodevelopmental disruption model based on prenatal administration of the polyriboinosinic-polyribocytidilic acid in rats, which mimics a viral infection and recapitulates behavioral abnormalities relevant to psychiatric disorders in the offspring. Extracellular dopamine levels were measured by brain microdialysis in both the nucleus accumbens shell and the medial prefrontal cortex, whereas dopamine neurons in ventral tegmental area were studied by in vivo electrophysiology.

resultsPolyriboinosinic-polyribocytidilic acid-treated animals, at adulthood, displayed deficits in sensorimotor gating, memory, and social interaction and increased baseline extracellular dopamine levels in the nucleus accumbens, but not in the prefrontal cortex. In polyriboinosinic-polyribocytidilic acid rats, dopamine neurons showed reduced spontaneously firing rate and population activity.

conclusionsThese results confirm that maternal immune activation severely impairs dopamine system and that the polyriboinosinic-polyribocytidilic acid model can be considered a proper animal model of a psychiatric condition that fulfills a multidimensional set of validity criteria predictive of a human pathology.

Indexed as

Action PotentialsAnimalsDisease Models, AnimalDopamineDopaminergic NeuronsFemaleMaleMemory DisordersMicrodialysisNucleus AccumbensPoly I-CPrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsRatsSensory GatingDopaminePoly I-CdopamineelectrophysiologymicrodialysisSchizophrenia

Identifiers

PMID26819283
PMCPMC4966272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.