ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
Cancer Incidence in Appalachia, 2004-2011.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Assessing the Effectiveness of Cancer Screening Interventions Targeting Appalachian Populations: A Systematic Review.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2021Pooled it
- Geographic disparities and temporal trends in aggressive prostate cancer: a SEER population-based analysis (2004-2022).Cancer causes & control : CCC · 2026Article
- Exploring Systemic Challenges in the Western North Carolina Dental Safety Net: A Qualitative Analysis.Journal of Appalachian health · 2026Article
- Understanding and predicting flossing behavior in a rural Appalachian community using the multi-theory model.Scientific reports · 2025Article
- Examining the role of freebase nicotine in the harm reduction potential of oral nicotine pouches versus moist snuff: A randomized crossover trial.Addiction (Abingdon, England) · 2025Article
- Disparities in Human Papillomavirus-Associated Cancer Incidence by Appalachian Residence.JAMA network open · 2025Article
- Examining Geographic Disparity: Variation in Cancer Outcomes Within Appalachia.Journal of the American College of Surgeons · 2025Article
- Testing oral nicotine pouches versus nicotine replacement therapy for cigarette harm reduction in Appalachia: The ARISE study protocol.PloS one · 2025Article
- Disparities in time to treatment initiation of invasive lung cancer among Black and White patients in Tennessee.PloS one · 2025Article
- Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening.Frontiers in immunology · 2025Article
- Risk of Colorectal Cancer among Patients with One or Multiple Metabolic Syndrome Components.Cancers · 2024Article
- Feasibility and efficacy of a novel audiovisual tool to increase colorectal cancer screening among rural Appalachian Kentucky adults.Frontiers in public health · 2024Article
- Extranodal Extension Improves AJCC-8 Accuracy in HPV+ Oropharyngeal Cancer in a High-Risk Population.The Laryngoscope · 2023Article
- Lung and Colorectal Cancer Disparities in Appalachian Kentucky: Spatial Analysis on the Influence of Education and Literacy.International journal of environmental research and public health · 2023Article
- Perceptions of oral nicotine pouches & their marketing among Ohio Appalachia smokers and smokeless tobacco users.PloS one · 2023Article
- Impact of community-driven interventions on dietary and physical activity outcomes among a cohort of adults in a rural Appalachian county in Eastern Kentucky, 2019-2022.Frontiers in public health · 2023Article
- Designing a Framework for Remote Cancer Care Through Community Co-design: Participatory Development Study.Journal of medical Internet research · 2022Article
- A cluster randomized controlled trial for a multi-level, clinic-based smoking cessation program with women in Appalachian communities: study protocol for the "Break Free" program.Addiction science & clinical practice · 2022Article
- Home Radon Testing in Rural Appalachia.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2022Article
- Sociodemographic Factors and Health Insurance Coverage Are Associated with Invasive Breast Cancer in Tennessee: Appalachian and Non-Appalachian County Comparison.Women's health reports (New Rochelle, N.Y.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLimited literature is available about cancer in the Appalachian Region. This is the only known analysis of all cancers for Appalachia and non-Appalachia covering 100% of the US population. Appalachian cancer incidence and trends were evaluated by state, sex, and race and compared with those found in non-Appalachian regions.
methodsUS counties were identified as Appalachian or non-Appalachian. Age-adjusted cancer incidence rates, standard errors, and confidence intervals were calculated using the most recent data from the United States Cancer Statistics for 2004 to 2011.
resultsGenerally, Appalachia carries a higher cancer burden compared with non-Appalachia, particularly for tobacco-related cancers. For all cancer sites combined, Appalachia has higher rates regardless of sex, race, or region. The Appalachia and non-Appalachia cancer incidence gap has narrowed, with the exception of oral cavity and pharynx, larynx, lung and bronchus, and thyroid cancers.
conclusionsHigher cancer incidence continues in Appalachia and appears at least in part to reflect high tobacco use and potential differences in socioeconomic status, other risk factors, patient health care utilization, or provider practices. It is important to continue to evaluate this population to monitor results from screening and early detection programs, understand behavioral risk factors related to cancer incidence, increase efforts to reduce tobacco use and increase cancer screening, and identify other areas where effective interventions may mediate disparities. IMPACT: Surveillance and evaluation of special populations provide means to monitor screening and early detection programs, understand behavioral risk factors, and increase efforts to reduce tobacco use to mediate disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.