Evidence map›Paper›PMID 26819252›Full record

ArticleJournal of the American Heart Association2016

Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study.

Wei Wang, Gui Shen, Eyal Shahar, Aurelian Bidulescu, W Taylor Kimberly, Kevin N Sheth, Brenda W Campbell, Steven Horbal, Adolfo Correa, Michael E Griswold

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Wei WangCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS (W.W., M.E.G.).
Gui ShenDepartment of Mathematics and Statistics, Mississippi State University, Mississippi State, MS (G.S.).
Eyal ShaharDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ (E.S.).
Aurelian BidulescuDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN (A.B., S.H.).
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital, Boston, MA (T.K.).
Kevin N ShethDivision of Neurocritical Care & Emergency Neurology, School of Medicine, Yale University, New Haven, CT (K.N.S.).
Brenda W CampbellJackson State University, Jackson, MS (B.W.C.).
Steven HorbalDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, IN (A.B., S.H.).
Adolfo CorreaJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS (A.C.).
Michael E GriswoldCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS (W.W., M.E.G.).
University of Mississippi Medical Center · USIndiana University Bloomington · USJackson State University · USMassachusetts General Hospital · USMississippi State University · USUniversity of Arizona · USYale University · US

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
NCATS NIH HHS UL1 TR001108NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050C
6 · The paper itself

Abstract

backgroundCigarette smoking is a risk factor for stroke, but the mechanisms by which smoking contributes to stroke are not well understood. This study aimed to evaluate the roles of lung function (represented by forced expiratory volume in the first second (FEV1)) and aldosterone as potential mediators of the association of smoking with stroke. METHODS AND

resultsThe data were derived from 5010 Jackson Heart Study participants who had mean follow-up of 97.9 months. Using the Cox proportional hazards model, we estimated the hazard ratios of smoking for total stroke with and without adjustment for FEV1 and/or aldosterone at baseline after controlling for the confounders. The hazard ratio for current smoking (versus never smoking) was 2.70 (95% CI 1.71 to 4.25) for total stroke after adjustment for the confounders. Additional adjustment for FEV1 and aldosterone reduced the hazard ratio to 2.32 (95% CI 1.42 to 3.79), suggesting that 22.4% of the excess risk of current smoking for total stroke is mediated by these factors. FEV1 and aldosterone account for 13.1% and 12.1%, respectively, of the excess risk. The hazard ratio for FEV1 increased (0.61 versus 0.65) after including systemic inflammatory marker C-reactive protein, and the hazard ratios for aldosterone were comparable for the models that included all confounders and smoking status with or without different blood pressure measurements.

conclusionsOur findings suggest that the difference in stroke risk between current and never smokers may develop partially through pathways involving lung function and aldosterone and that the mediation effect through aldosterone is independent of blood pressure.

Indexed as

Black or African AmericanForced Expiratory VolumeAdultAgedAldosteroneBiomarkersBlood PressureFemaleHumansLinear ModelsLungMaleMiddle AgedMississippiMultivariate AnalysisProportional Hazards ModelsAldosteroneBiomarkersaldosteronelung functionmediation effectssmokingstroke

Identifiers

PMID26819252
PMCPMC4859388
OpenAlexW2295679554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.