Evidence map›Paper›PMID 26819218›Full record

ArticleBMC complementary and alternative medicine2016

In vitro antibacterial activity of selected medicinal plants traditionally used in Vietnam against human pathogenic bacteria.

Thuy Thu Vu, Hyungrok Kim, Vu Khac Tran, Quang Le Dang, Hoa Thi Nguyen, Hun Kim, In Seon Kim, Gyung Ja Choi, Jin-Cheol Kim

Open access · goldAbstract read
In one paragraph

Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
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  8. Assessment ofPlants (Basel, Switzerland) · 2022
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  13. Food science & nutrition · 2021
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  14. Article
  15. Article
  16. The Antimicrobial Activity of Cannabinoids.Antibiotics (Basel, Switzerland) · 2020
    Review
  17. Review
  18. Article
  19. The Cytotoxic Properties ofEvidence-based complementary and alternative medicine : eCAM · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Thuy Thu VuDepartment of Green Chemistry and Environmental Biotechnology, Korea University of Science and Technology, 217 Gajeong-Ro, Yuseong-Gu, Daejeon, 305-333, Republic of Korea.
Hyungrok KimDivision of Green Chemistry and Engineering, Korea Research Institute of Chemical Technology, 141 Gajeong-Ro, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
Vu Khac TranDepartment of Pharmaceutical Chemistry and Pesticides Technology, School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam.
Quang Le DangResearch and Development Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry (VIIC), No. 2 Pham Ngu Lao, Hoan Kiem, Hanoi, Vietnam.
Hoa Thi NguyenResearch and Development Center of Bioactive Compounds, Vietnam Institute of Industrial Chemistry (VIIC), No. 2 Pham Ngu Lao, Hoan Kiem, Hanoi, Vietnam.
Hun KimDivision of Bio and Drug Discovery, Korea Research Institute of Chemical Technology, 141 Gajeong-Ro, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
In Seon KimDivision of Applied Bioscience and Biotechnology, Institute of Environmentally Friendly Agriculture, College of Agriculture and Life Sciences, Chonnam National University, 77 Yongbong-Ro, Buk-Gu, Gwangju, 500-757, Republic of Korea.
Gyung Ja ChoiDepartment of Green Chemistry and Environmental Biotechnology, Korea University of Science and Technology, 217 Gajeong-Ro, Yuseong-Gu, Daejeon, 305-333, Republic of Korea. kjchoi@krict.re.kr.
Jin-Cheol KimDivision of Applied Bioscience and Biotechnology, Institute of Environmentally Friendly Agriculture, College of Agriculture and Life Sciences, Chonnam National University, 77 Yongbong-Ro, Buk-Gu, Gwangju, 500-757, Republic of Korea. kjinc@jnu.ac.kr.
Korea Research Institute of Chemical Technology · KRAgricultural Genetics Institute · VNChonnam National University · KRHanoi University of Science and Technology · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedicinal plants are widely used for the treatment of different infectious diseases. Infectious diseases caused by bacteria have a large impact on public health. This study aimed to determine the in vitro antibacterial activity of the medicinal plants traditionally used in Vietnam against the bacterial strains associated with infectious diseases.

methodsMethanol extracts of twelve Vietnamese medicinal plants were tested for their antibacterial activity against five bacterial species including Gram-positive bacteria (Bacillus cereus, Bacillus subtilis, and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using the broth microdilution method.

resultsAll the plant extracts showed antibacterial activity, especially against Gram-positive bacteria (Bacillus cereus, Bacillus subtilis, and Staphylococcus aureus). Baeckea frutescens extract revealed a potent activity against the Gram-positive bacteria with the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 62.5 μg/ml. High activity against all the three Gram-positive bacteria was also observed for the extracts of Cratoxylum formosum ssp. pruniflorum, Pogostemon cablin, and Pedilanthus tithymaloides with MICs of 125, 125 and 250 μg/ml and MBCs of 125-250, 125-250 and 250-500 μg/ml, respectively. The extracts of C. formosum ssp. pruniflorum and P. tithymaloides showed a broad-spectrum antibacterial activity against all the bacteria tested with the MICs of 125-2,000 μg/ml.

conclusionThis study indicates clear evidence supporting the traditional use of the plants in treating infectious diseases related to bacteria. In particular, these plant species showed moderate to high antibacterial activity against the Gram-positive bacteria tested.

Indexed as

Anti-Bacterial AgentsGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsPlant ExtractsPlants, MedicinalVietnamAnti-Bacterial AgentsPlant Extracts

Identifiers

PMID26819218
PMCPMC4728873
OpenAlexW2265592223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.