ArticleBMC genomics2016
Comprehensive identification of sexually dimorphic genes in diverse cattle tissues using RNA-seq.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of prenatal transportation stress on liver gene expression in male and female Brahman calves.Frontiers in genetics · 2026Article
- Comparative Single-Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Developmental programming: Sex-specific effects of prenatal exposure to a real-life mixture of environmental chemicals on liver function and transcriptome in sheep.Environmental pollution (Barking, Essex : 1987) · 2025Article
- An Integrated Database for Exploring Alternative Promoters in Animals.Scientific data · 2025Article
- Paternal impact on the developmental programming of sexual dimorphism.Frontiers in cell and developmental biology · 2024Review
- Integrated analyses of the methylome and transcriptome to unravel sex differences in the perirenal fat from suckling lambs.Frontiers in genetics · 2022Article
- Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle.Frontiers in genetics · 2022Article
- Multipopulational transcriptome analysis of post-weaned beef cattle at arrival further validates candidate biomarkers for predicting clinical bovine respiratory disease.Scientific reports · 2021Article
- Identification of genomic regions that exhibit sexual dimorphism for size and muscularity in cattle.Journal of animal science · 2021Article
- Transcriptome Analysis of Zebrafish Olfactory Epithelium Reveal Sexual Differences in Odorant Detection.Genes · 2020Article
- Tissue-specific sex differences in human gene expression.Human molecular genetics · 2019Article
- Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.Science (New York, N.Y.) · 2019Article
- Multi-tissue observation of the long non-coding RNA effects on sexually biased gene expression in cattle.Asian-Australasian journal of animal sciences · 2019Article
- Resolving the Insertion Sites of Polymorphic Duplications Reveals a HERC2 Haplotype under Selection.Genome biology and evolution · 2019Article
- Comparative Analysis of the Liver Transcriptome among Cattle Breeds Using RNA-seq.Veterinary sciences · 2019Article
- Machine learning applied to transcriptomic data to identify genes associated with feed efficiency in pigs.Genetics, selection, evolution : GSE · 2019Article
- The role of sex in the genomics of human complex traits.Nature reviews. Genetics · 2019Review
- Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues.Genome biology and evolution · 2019Article
- Gene co-expression networks in liver and muscle transcriptome reveal sex-specific gene expression in lambs fed with a mix of essential oils.BMC genomics · 2018Article
- Autosomal genetic control of human gene expression does not differ across the sexes.Genome biology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMolecular mechanisms associated with sexual dimorphism in cattle have not been well elucidated. Furthermore, as recent studies have implied that gene expression patterns are highly tissue specific, it is essential to investigate gene expression in a variety of tissues using RNA-seq. Here, we employed and compared two statistical methods, a simple two group test and Analysis of deviance (ANODEV), in order to investigate bovine sexually dimorphic genes in 40 RNA-seq samples distributed across two factors: sex and tissue.
resultsAs a result, we detected 752 sexually dimorphic genes across tissues from two statistical approaches and identified strong tissue-specific patterns of gene expression. Additionally, significantly detected sex-related genes shared between two mammal species (cattle and rat) were identified using qRT-PCR.
conclusionsResults of our analyses reveal that sexual dimorphism of metabolic tissues and pituitary gland in cattle involves various biological processes. Several differentially expressed genes between sexes in cattle and rat species are shared, but show tissue-specific patterns. Finally, we concluded that two distinct statistical approaches have their advantages and disadvantages in RNA-seq studies investigating multiple tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.