SynthesisNature communications2016
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 6 pooled it
24.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 6 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.Communications biology · 2022Pooled it
- A Genome-Wide Association Study of Prediabetes Status Change.Frontiers in endocrinology · 2022Pooled it
- Pooled it
- Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.Nature genetics · 2019Pooled it
- A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations.PLoS genetics · 2016Pooled it
- Association between -308G/A TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review.Journal of diabetes research · 2016Pooled it
- Evolutionary history of disease-susceptibility loci identified in longitudinal exome-wide association studies.Molecular genetics & genomic medicine · 2019Trial
- Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with type 2 diabetes.Molecular and cellular biochemistry · 2019Trial
- Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026Review
- Genetic background of obesity: a case-control study.Hormones (Athens, Greece) · 2026Article
- ROME, an Ancient Gene with a Novel Function in Vertebrates, Is a Key Modulator of Embryonal Development and Cancer Metastasis.Cancer research communications · 2026Article
- RWDisEnh+: Enhancing disease-enhancer association prediction through multiplex-heterogeneous networks.PloS one · 2026Article
- Article
- Pathway insights and predictive modeling for type 2 diabetes using polygenic risk scores.Scientific reports · 2025Article
- Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations.medRxiv : the preprint server for health sciences · 2025Article
- Linking Genome-Wide Association Studies to Pharmacological Treatments for Psychiatric Disorders.JAMA psychiatry · 2025Article
- Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.Human heredity · 2025Article
- A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetite.bioRxiv : the preprint server for biology · 2024Article
- Genetic studies of type 2 diabetes, and microvascular complications of diabetes.Diabetology international · 2024Review
- Genome-wide association study on meningioma risk in Japan: a multicenter prospective study.Journal of neuro-oncology · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
63 authors at 20 institutions in 12 countries.
Minako ImamuraLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Kazuo HaraDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Kazuki YasudaDepartment of Metabolic Disorder, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Niels GrarupThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.ORCID http://orcid.org/0000-0002-8301-9297
Xu WangSaw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore.
Alicia Huerta-ChagoyaUnidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico.
Cheng HuDepartment of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Sanghoon MoonDivision of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.
Soo Heon KwakDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
Richa SaxenaCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Ronald C W MaDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Minoru IwataFirst Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Jun HosoeDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Nobuhiro ShojimaDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Minaka IwasakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Hayato FujitaDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Ken SuzukiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge CB1 8RN, UK.
Torben JørgensenResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup DK-2600, Denmark.
Marit E JørgensenSteno Diabetes Center, Gentofte 2820, Denmark.
Daniel R WitteDepartment of Public Health, Aarhus University, Aarhus 8000, Denmark.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle 7100, Denmark.
Cramer ChristensenMedical Department, Lillebaelt Hospital, Vejle 7100, Denmark.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Josep M MercaderProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Jason FlannickProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Hortensia Moreno-MacíasUniversidad Autónomas Metropolitana, Mexico City 09340, Mexico.
Noël P BurttProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Rong ZhangDepartment of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Young Jin KimDivision of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.
Jai Rup SinghCentral University of Punjab, Bathinda, Punjab 151001, India.
Claudia H T TamDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Hiroshi HiroseHealth Center, Keio University, Tokyo 160-8582, Japan.
Hiroshi MaegawaDepartment of Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.
Chikako ItoGrand Tower Medical Court Life Care Clinic, Hiroshima 730-0012, Japan.
Kohei KakuDepartment of Internal Medicine, Kawasaki Medical School, Kurashiki 701-0192, Japan.
Hirotaka WatadaDepartment of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.ORCID http://orcid.org/0000-0001-5961-1816
Yasushi TanakaDivision of Metabolism and Endocrinology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki 216-8511, Japan.
Kazuyuki TobeFirst Department of Internal Medicine, University of Toyama, Toyama 930-0194, Japan.
Ryuzo KawamoriSportology Center, Juntendo University Graduate School of Medicine, Tokyo 113-0034, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Yoon Shin ChoDepartment of Biomedical Science, Hallym University, Chunchon, Gangwon-do 24252, Republic of Korea.
Juliana C N ChanDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Dharambir SangheraDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Philippe FrossardCenter for Non-Communicable Diseases, Karachi, Pakistan.
Kyong Soo ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.
Bong-Jo KimDivision of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 28159, Korea.
Jose C FlorezProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.
Teresa Tusié-LunaUnidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City C.P.14000, Mexico.
Weiping JiaDepartment of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore 138672, Singapore.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Danish SaleheenDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6021, USA.
Shiro MaedaLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
The University of Tokyo · JPBroad Institute · USUniversity of Copenhagen · DKCenter for Non-Communicable Diseases · PKChinese University of Hong Kong · HKKorea National Institute of Health · KRShanghai Jiao Tong University · CNVanderbilt University · USInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXJuntendo University · JPNational University of Singapore · SGRIKEN Center for Integrative Medical Sciences · JPUniversity of Toyama · JPAarhus University · DKCentral University of Punjab · INHallym University · KRHigashihiroshima Medical Center · JPKawasaki Medical School · JPKeio University · JPLillebaelt Hospital · DK
Funding
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MShanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8MCancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7MGenetic Factors for Breast Cancer- A genome Wide StudyR01CA124558 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2008 to 2012
$3.1MGenome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in AsianR01DK082766 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SANGHERA, DHARAMBIR K. · 2009 to 2011
$2.3MIndo-US Collaboration in Genomic Studies on DiabetesK01TW006087 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANGHERA, DHARAMBIR K · 2002 to 2007
$778kBritish Heart Foundation SP/09/002European Research Council 268834FIC NIH HHS K01 TW006087FIC NIH HHS KO1TW006087Medical Research Council G0800270NCI NIH HHS BC050791NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA124558NCI NIH HHS R01CA124558NCI NIH HHS R01CA64277NCI NIH HHS R37 CA070867NCI NIH HHS R37CA070867NCI NIH HHS UM1 CA182910NCRR NIH HHS UL1 RR024975NIDDK NIH HHS R01 DK082766NIDDK NIH HHS R01DK082766Wellcome Trust
Abstract
Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.
Indexed as
Genetic Predisposition to DiseaseAsian PeopleCase-Control StudiesDiabetes Mellitus, Type 2DNA-Binding ProteinsGenome-Wide Association StudyHumansJapanPolymorphism, Single NucleotideSuppressor of Cytokine Signaling ProteinsTranscription FactorsASB3 protein, humanDMRTA1 protein, humanDNA-Binding ProteinsSINHCAF protein, humanSuppressor of Cytokine Signaling ProteinsTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.