ArticlePlant physiology2016
SEUSS Integrates Gibberellin Signaling with Transcriptional Inputs from the SHR-SCR-SCL3 Module to Regulate Middle Cortex Formation in the Arabidopsis Root.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 63 citations in OpenAlex.
- Strigolactones Regulate Sugar Allocation to Control Rice Tillering and Root Development via the OsSPL14-OsSHR1-OsSWEET16 Pathway.Plant biotechnology journal · 2026Article
- ROS-mediated interplay between brassinosteroids and gibberellic acids antagonistically modulates asymmetric periclinal cell division leading to middle cortex formation inPlant signaling & behavior · 2025Article
- Integrative regulation of middle cortex formation: from classic modules to emerging pathways.Frontiers in plant science · 2025Review
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- GWAS for the identification of introgressed candidate genes ofFrontiers in plant science · 2024Article
- JcSEUSS1 negatively regulates reproductive organ development in perennial woody Jatropha curcas.Planta · 2023Article
- Agronomic and hormonal approaches for enhancing flowering intensity in white Guinea yam (Frontiers in plant science · 2023Article
- Transcriptional control of hydrogen peroxide homeostasis regulates ground tissue patterning in theFrontiers in plant science · 2023Article
- Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis.Nature chemical biology · 2022Article
- Salicylic Acid in Root Growth and Development.International journal of molecular sciences · 2022Review
- It's Time for a Change: The Role of Gibberellin in Root Meristem Development.Frontiers in plant science · 2022Review
- Non-cell autonomous and spatiotemporal signalling from a tissue organizer orchestrates root vascular development.Nature plants · 2021Article
- Root stem cell niche networks: it's complexed! Insights from Arabidopsis.Journal of experimental botany · 2021Article
- SCARECROW-LIKE3 regulates the transcription of gibberellin-related genes by acting as a transcriptional co-repressor of GAI-ASSOCIATED FACTOR1.Plant molecular biology · 2021Article
- A PHABULOSA-Controlled Genetic Pathway Regulates Ground Tissue Patterning in the Arabidopsis Root.Current biology : CB · 2021Article
- Root Patterning: Tuning SHORT ROOT Function Creates Diversity in Form.Frontiers in plant science · 2021Review
- Transcriptomic analysis reveals the GRAS family genes respond to gibberellin in Salvia miltiorrhiza hairy roots.BMC genomics · 2020Article
- SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification.The EMBO journal · 2020Article
- SIZ1-Mediated SUMO Modification of SEUSS Regulates Photomorphogenesis inPlant communications · 2020Article
- Protein complex stoichiometry and expression dynamics of transcription factors modulate stem cell division.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A decade of studies on middle cortex (MC) formation in the root endodermis of Arabidopsis (Arabidopsis thaliana) have revealed a complex regulatory network that is orchestrated by several GRAS family transcription factors, including SHORT-ROOT (SHR), SCARECROW (SCR), and SCARECROW-LIKE3 (SCL3). However, how their functions are regulated remains obscure. Here we show that mutations in the SEUSS (SEU) gene led to a higher frequency of MC formation. seu mutants had strongly reduced expression of SHR, SCR, and SCL3, suggesting that SEU positively regulates these genes. Our results further indicate that SEU physically associates with upstream regulatory sequences of SHR, SCR, and SCL3; and that SEU has distinct genetic interactions with these genes in the control of MC formation, with SCL3 being epistatic to SEU. Similar to SCL3, SEU was repressed by the phytohormone GA and induced by the GA biosynthesis inhibitor paclobutrazol, suggesting that SEU acts downstream of GA signaling to regulate MC formation. Consistently, we found that SEU mediates the regulation of SCL3 by GA signaling. Together, our study identifies SEU as a new critical player that integrates GA signaling with transcriptional inputs from the SHR-SCR-SCL3 module to regulate MC formation in the Arabidopsis root.
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