Evidence map›Paper›PMID 26818586›Full record

Trial reportPhysiological reports2016

Impact of resistance exercise on ribosome biogenesis is acutely regulated by post-exercise recovery strategies.

Vandré C Figueiredo, Llion A Roberts, James F Markworth, Matthew P G Barnett, Jeff S Coombes, Truls Raastad, Jonathan M Peake, David Cameron-Smith

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Vandré C FigueiredoThe Liggins Institute, The University of Auckland, Auckland, New Zealand.
Llion A RobertsSchool of Human Movement and Nutrition Sciences The University of Queensland, Brisbane, Australia Centre of Excellence for Applied Sport Science Research, Queensland Academy of Sport, Brisbane, Australia.
James F MarkworthThe Liggins Institute, The University of Auckland, Auckland, New Zealand.
Matthew P G BarnettAgResearch Limited, Grasslands Research Centre, Palmerston North, New Zealand.
Jeff S CoombesSchool of Human Movement and Nutrition Sciences The University of Queensland, Brisbane, Australia.
Truls RaastadNorwegian School of Sport Sciences, Oslo, Norway.
Jonathan M PeakeCentre of Excellence for Applied Sport Science Research, Queensland Academy of Sport, Brisbane, Australia School of Biomedical Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
David Cameron-SmithThe Liggins Institute, The University of Auckland, Auckland, New Zealand d.cameron-smith@auckland.ac.nz.
University of Auckland · NZQueensland Academy of Sport · AUAgResearch · NZNorwegian School of Sport Sciences · NOThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training-induced skeletal muscle hypertrophy. The time course of ribosome biogenesis following resistance exercise (RE) and the impact exerted by differing recovery strategies remains unknown. In the present study, the activation of transcriptional regulators, the expression levels of pre-rRNA, and mature rRNA components were measured through 48 h after a single-bout RE. In addition, the effects of either low-intensity cycling (active recovery, ACT) or a cold-water immersion (CWI) recovery strategy were compared. Nine male subjects performed two bouts of high-load RE randomized to be followed by 10 min of either ACT or CWI. Muscle biopsies were collected before RE and at 2, 24, and 48 h after RE. RE increased the phosphorylation of the p38-MNK1-eIF4E axis, an effect only evident with ACT recovery. Downstream, cyclin D1 protein, total eIF4E, upstream binding factor 1 (UBF1), and c-Myc proteins were all increased only after RE with ACT. This corresponded with elevated abundance of the pre-rRNAs (45S, ITS-28S, ITS-5.8S, and ETS-18S) from 24 h after RE with ACT. In conclusion, coordinated upstream signaling and activation of transcriptional factors stimulated pre-rRNA expression after RE. CWI, as a recovery strategy, markedly blunted these events, suggesting that suppressed ribosome biogenesis may be one factor contributing to the impaired hypertrophic response observed when CWI is used regularly after exercise.

Indexed as

Blotting, WesternCold TemperatureCross-Over StudiesHumansMaleMuscle, SkeletalResistance TrainingReverse Transcriptase Polymerase Chain ReactionRibosomesYoung AdultCyclin D1hypertrophypre‐rRNAribosomal RNAskeletal muscleupstream binding factor

Identifiers

PMID26818586
PMCPMC4760384
OpenAlexW2257943861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.