Evidence map›Paper›PMID 26818247›Full record

ArticleBMC ophthalmology2015

Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome.

Chia-Yang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Bacteria and Dry Eye: A Narrative Review.Journal of clinical medicine · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Chia-Yang LiuEdith J. Crawley Vision Research Center/Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267-0838, USA. liuchia@iu.edu.
University of Cincinnati · US

Funding

Mouse Model for Eyelid Disease: Congenital BlepharophimosisR01EY021501 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2011 to 2015
$1.9M
New Insights into the Ocular Surface in Health and DiseaseR01EY023680 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI LIU, CHIA-YANG · 2015 to 2017
$1.3M
NEI NIH HHS NIH/NEI RO1 EY21501NEI NIH HHS R01 EY021501NEI NIH HHS R01 EY023680
6 · The paper itself

Abstract

This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). Specifically, we used novel transgenic mice to investigate the mechanism of how the Notch1 activation may serve as the upstream control of expression of transcription factors Krüppel-like factors 4 or 5 (Klf4 or Klf5) which in turn controls goblet cell differentiation and activates mucin 5/ac synthesis during ocular surface morphogenesis.

Indexed as

AnimalsCell DifferentiationCongresses as TopicConjunctivaDNA-Binding ProteinsDry Eye SyndromesGoblet CellsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceReceptor, Notch1Signal TransductionTranscription FactorsDNA-Binding ProteinsKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsMAML1 protein, humanReceptor, Notch1Transcription Factors

Identifiers

PMID26818247
PMCPMC4895251
OpenAlexW2225651649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.