Evidence map›Paper›PMID 26818228›Full record

Trial reportDiabetes & vascular disease research2016

A randomised controlled trial evaluating the impact of targeted vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial.

Rinkoo Dalan, Huiling Liew, Pryseley Nkouibert Assam, Edwin Sy Chan, Fahad Javaid Siddiqui, Alvin Wk Tan, Daniel Ek Chew, Bernhard O Boehm, Melvin Ks Leow

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes & vascular disease research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  18. Vitamin D and cardiovascular health.Clinical nutrition (Edinburgh, Scotland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rinkoo DalanDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore Yong Loo Lin School of Medicine, National University of Singapore, Singapore DUKE-NUS Medical School, National University of Singapore, Singapore Metabolic Medicine Research Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore rinkoo_dalan@ttsh.com.sg.
Huiling LiewDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore.
Pryseley Nkouibert AssamDepartment of Biostatistics, Singapore Clinical Research Institute, Singapore Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
Edwin Sy ChanDepartment of Biostatistics, Singapore Clinical Research Institute, Singapore Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
Fahad Javaid SiddiquiDepartment of Biostatistics, Singapore Clinical Research Institute, Singapore Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, National University of Singapore, Singapore.
Alvin Wk TanDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore.
Daniel Ek ChewDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore.
Bernhard O BoehmDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore Metabolic Medicine Research Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Imperial College London, London, UK.
Melvin Ks LeowDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore Singapore Institute for Clinical Sciences, A*STAR, Singapore National Healthcare Group, Singapore.
Tan Tock Seng Hospital · SGDuke-NUS Medical School · SGSingapore Clinical Research Institute · SGSingapore Institute for Clinical Sciences · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to determine if vitamin D supplementation, to target 25(OH)D concentrations of 30-40 ng/mL, improves endothelial function in Singapore's multi-ethnic type 2 diabetes mellitus population. We randomised 64 type 2 diabetes mellitus patients with hypovitaminosis D to cholecalciferol 4000 International Unit/matching placebo [baseline 25(OH)D < 20 ng/mL] or cholecalciferol 2000 International Unit/matching placebo [baseline 25(OH)D: 20-30 ng/mL] daily for 16 weeks with a down titration at 8 weeks if 25(OH)D > 30 ng/mL. Endothelial function was assessed by peripheral tonometry (reactive hyperaemia index-endothelial peripheral arterial tonometry) and vascular biomarkers: E-selectin, von-Willebrand factor and high-sensitivity C-reactive protein. We compared the change from baseline parameters in the two groups using Student's t-test or Kruskal-Wallis test. A log-normal multivariate regression analysis was used to adjust for relevant baseline variables. The median reactive hyperaemia index in the vitamin D group increased from 0.65 (interquartile range: 0.42) to 0.73 (interquartile range: 0.36), whereas it decreased from 0.73 (interquartile range: 0.65) to 0.65 (interquartile range: 0.38) (p = 0.02) in the placebo group. After adjustment for baseline variables, the change was not statistically significant for reactive hyperaemia index (p = 0.07) and for other vascular biomarkers (p > 0.05). Targeted vitamin D supplementation for 16 weeks resulted in a small but non-significant improvement in endothelial function in a type 2 diabetes mellitus cohort.

Indexed as

Dietary SupplementsAdultAgedBiomarkersCholecalciferolDiabetes Mellitus, Type 2Diabetic AngiopathiesDouble-Blind MethodEndothelium, VascularFemaleHumansHyperemiaMaleMiddle AgedSingaporeTertiary Care Centers25-hydroxyvitamin DBiomarkersCholecalciferolVitamin Dcholecalciferolendothelial functiontype 2 diabetesVitamin D

Identifiers

PMID26818228
PMCPMC4834510
OpenAlexW2259183329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.