ArticleG3 (Bethesda, Md.)2016
Drak Is Required for Actomyosin Organization During Drosophila Cellularization.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Drak is a potential binding partner of Drosophila Filamin.Biology open · 2026Article
- STK17A (DRAK1) at the crossroads of apoptosis, immunity, and cancer: Emerging roles and therapeutic opportunities.Theranostics · 2026Review
- DRAK2 regulates myosin light chain phosphorylation in T cells.Journal of cell science · 2024Article
- Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila.The Journal of cell biology · 2024Article
- FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.Development (Cambridge, England) · 2023Article
- Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization.Seminars in cell & developmental biology · 2023Review
- A Comparative Study of the Role of Formins inCells · 2022Article
- Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.PLoS computational biology · 2021Article
- Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction ineLife · 2021Article
- The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems.Frontiers in cellular and infection microbiology · 2021Review
- Anillin facilitates cell proliferation and induces tumor growth of hepatocellular carcinoma via miR-138/SOX4 axis regulation.Translational oncology · 2020Article
- Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.Development (Cambridge, England) · 2019Article
- Protein Kinase D Is Dispensable for Development and Survival ofG3 (Bethesda, Md.) · 2019Article
- TheMolecular biology of the cell · 2019Article
- Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.Cancer research · 2019Article
- Genetic interactions betweenHereditas · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The generation of force by actomyosin contraction is critical for a variety of cellular and developmental processes. Nonmuscle myosin II is the motor that drives actomyosin contraction, and its activity is largely regulated by phosphorylation of the myosin regulatory light chain. During the formation of the Drosophila cellular blastoderm, actomyosin contraction drives constriction of microfilament rings, modified cytokinesis rings. Here, we find that Drak is necessary for most of the phosphorylation of the myosin regulatory light chain during cellularization. We show that Drak is required for organization of myosin II within the microfilament rings. Proper actomyosin contraction of the microfilament rings during cellularization also requires Drak activity. Constitutive activation of myosin regulatory light chain bypasses the requirement for Drak, suggesting that actomyosin organization and contraction are mediated through Drak's regulation of myosin activity. Drak is also involved in the maintenance of furrow canal structure and lateral plasma membrane integrity during cellularization. Together, our observations suggest that Drak is the primary regulator of actomyosin dynamics during cellularization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.