ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2016
Validation of a Behavioral Ethogram for Assessing Postoperative Pain in Guinea Pigs (Cavia porcellus).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Otitis in pet guinea pigs: Causes, clinical signs, treatment and outcomes.The Veterinary record · 2026Article
- Guinea pig meat production in South America: Reviewing existing practices, welfare challenges, and opportunities.Animal welfare (South Mimms, England) · 2025Review
- Relationship between Ear Temperature, Behaviour and Stress Hormones in Guinea Pigs (Animals : an open access journal from MDPI · 2024Article
- Review of Rat (Animals : an open access journal from MDPI · 2023Review
- Validation of the rabbit pain behaviour scale (RPBS) to assess acute postoperative pain in rabbits (Oryctolagus cuniculus).PloS one · 2022Article
- Indicators of Postoperative Pain in Syrian Hamsters (Comparative medicine · 2021Article
- Grimace Scores: Tools to Support the Identification of Pain in Mammals Used in Research.Animals : an open access journal from MDPI · 2020Review
- Investigation of Various Intramuscular Volumes Delivered to the Semimembranosus Muscle ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2020Article
- Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence.PloS one · 2020Article
- A Review of Pain Assessment Methods in Laboratory Rodents.Comparative medicine · 2019Review
- Clinical Management of Pain in Rodents.Comparative medicine · 2019Review
- Assessing Affective State in Laboratory Rodents to Promote Animal Welfare-What Is the Progress in Applied Refinement Research?Animals : an open access journal from MDPI · 2019Review
- Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2018Article
- Humane Endpoints for Guinea Pigs Used forComparative medicine · 2018Article
- Pharmacokinetics and Adverse Effects of 3 Sustained-release Buprenorphine Dosages in Healthy Guinea Pigs (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- Evaluation of Using Behavioural Changes to Assess Post-Operative Pain in the Guinea Pig (Cavia porcellus).PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although guinea pigs (Cavia porcellus) have been used in research for more than a century and remain the most prevalent USDA-covered species, little has been elucidated regarding the recognition of clinical pain or analgesic efficacy in this species. We sought to assess pain in guinea pigs by using newer, clinically relevant methods that have been validated in other rodent species: the behavioral ethogram and cageside proxy indicator. In this study, 10 male guinea pigs underwent electronic von Frey testing of nociception, remote videorecording of behavior, and cageside assessment by using time-to-consumption (TTC) of a preferred treat test. These assessments were performed across 2 conditions (anesthesia only and castration surgery under anesthesia) at 3 time points (2, 8, and 24 h after the event). The anesthesia only condition served to control for the nonpainful but potentially distressing components of the surgical experience. Compared with those after anesthesia only conditions, subtle body movements were increased and nociceptive thresholds were decreased at 2 and 8 h after surgery. At 24 h, neither subtle body movement behaviors nor nociceptive thresholds differed between the 2 conditions. In contrast, TTC scores did not differ between the anesthesia only and surgery conditions at any time point, underscoring the challenge of identifying pain in this species through cageside evaluation. By comparing ethogram scores with measures of nociception, we validated select behaviors as pain-specific. Therefore, our novel ethogram allowed us to assess postoperative pain and may further serve as a platform for future analgesia efficacy studies in guinea pigs.
Indexed as
Identifiers
26817977PMC4747008W2434417597What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.