ReviewAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2016
How May Proton Pump Inhibitors Impair Cardiovascular Health?
Review in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Proton pump inhibitors and risk of hearing loss; a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials.BMC medicine · 2021Pooled it
- Proton Pump Inhibitors and Biomarkers of Haemostasis in Postmenopausal Women: The Buffalo OsteoPerio Study.Basic & clinical pharmacology & toxicology · 2026Article
- Association Between Polypharmacy and Self-Reported Hearing Disability: An Observational Study Using ATC Classification and HHIE-S-It Questionnaire.Audiology research · 2025Article
- Proton Pump Inhibitor Use and Incident Hypertension in Menopausal Women.Journal of the American Heart Association · 2025Observational
- Proton Pump Inhibitor Use and Incident Cardiovascular Disease in Older Postmenopausal Women.Journal of the American Geriatrics Society · 2025Observational
- Interplay between dietary nitrate metabolism and proton pump inhibitors: impact on nitric oxide pathways and health outcomes.Frontiers in nutrition · 2025Review
- Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?Pharmaceuticals (Basel, Switzerland) · 2023Review
- Article
- Current management of gastro-oesophageal reflux disease-treatment costs, safety profile, and effectiveness: a narrative review.Gastroenterology report · 2023Review
- Twenty-three medication-taking traits and stroke: A comprehensive Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Association of Proton Pump Inhibitors With Higher Risk of Cardiovascular Disease and Heart Failure.Mayo Clinic proceedings · 2021Article
- Association between Proton Pump Inhibitors and Hearing Impairment: A Nested Case-Control Study.Current issues in molecular biology · 2021Article
- A Contemporary Look at Biomechanical Models of Myocardium.Annual review of biomedical engineering · 2019Review
- Possible Effects of Proton Pump Inhibitors on Hearing Loss Development.BioMed research international · 2019Review
- Proton-pump Inhibitor Use and Fracture Risk: An Updated Systematic Review and Meta-analysis.Journal of bone metabolism · 2018Article
- Update on assessment and management of primary cardiac involvement in systemic sclerosis.Journal of scleroderma and related disorders · 2018Review
- Nonsteroidal anti-inflammatory drugs in chronic pain: implications of new data for clinical practice.Journal of pain research · 2018Review
- Surgical Treatment of Gastroesophageal Reflux Disease.World journal of surgery · 2017Review
- Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction.Redox biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. They are used to treat a number of gastroesophageal disorders and are usually prescribed as a long-term medication or even taken without a prescription. There are a number of clinical studies that associate PPI use with an increased cardiovascular risk. In this article, we review the clinical evidence for adverse cardiovascular effects of PPIs, and we discuss possible biological mechanisms by which PPIs can impair cardiovascular health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.