ArticleMedicine2016
Antineutrophil Cytoplasmic Antibodies Associated With Infective Endocarditis.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Antineutrophil cytoplasmic antibodies in infective endocarditis: a case report and systematic review of the literature.Clinical rheumatology · 2022Pooled it
- Enterotoxigenic Escherichia coli Type O6-related Cytoplasmic Anti-neutrophil Cytoplasmic Antibody-positive Necrotizing Glomerulitis Diagnosed by Indirect Immunofluorescence.Internal medicine (Tokyo, Japan) · 2026Article
- Successful Management of Infective Endocarditis Utilizing Rapid High-performance Liquid Chromatography-based Therapeutic Drug Monitoring: Balancing Linezolid Efficacy and Thrombocytopenia Risk.Internal medicine (Tokyo, Japan) · 2026Article
- Article
- Granulicatella adiacens Endocarditis Mimicking an Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.JACC. Case reports · 2025Article
- Article
- Article
- Review
- Article
- Uncommon onset manifestations without renal involvement in microscopic polyangiitis: A case report.Experimental and therapeutic medicine · 2022Article
- Endocarditis-associated rapidly progressive glomerulonephritis mimicking vasculitis: a diagnostic and treatment challenge.Annals of medicine · 2022Article
- The clinical pattern differentiates ANCA-positive infective endocarditis patients from ANCA-associated vasculitis patients: a 23 years' retrospective cohort study in China and follow-ups.Clinical rheumatology · 2022Article
- ANCA-associated vasculitis with cardiac valve vegetations in two teenage males: two case reports and a literature review.Pediatric rheumatology online journal · 2022Review
- A case of infective endocarditis mimicking antineutrophil cytoplasmic antibody-associated vasculitis.Journal of cardiology cases · 2022Article
- Infective Endocarditis-Associated Glomerulonephritis: A Comprehensive Review of the Clinical Presentation, Histopathology, and Management.Yonago acta medica · 2022Review
- Glomerulonephritis Caused by Bartonella spp. Infective Endocarditis: The Difficulty and Importance of Differentiation from Anti-neutrophil Cytoplasmic Antibody-related Rapidly Progressive Glomerulonephritis.Internal medicine (Tokyo, Japan) · 2021Article
- ANCA testing: where are we now?Internal and emergency medicine · 2021Article
- Antineutrophil cytoplasmic antibody-positive infective endocarditis complicated by acute kidney injury: a case report and literature review.The Journal of international medical research · 2020Review
- Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature.Journal of medical case reports · 2020Review
- Relapses in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective study.Clinical rheumatology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the prevalence of antineutrophil cytoplasmic antibodies (ANCA) in patients with infective endocarditis (IE) in internal medicine; and to compare clinical and biochemical features and outcome between patients exhibiting IE with and without ANCA.Fifty consecutive patients with IE underwent ANCA testing. The medical records of these patients were reviewed.Of the 50 patients with IE, 12 exhibited ANCA (24%). ANCA-positive patients with IE exhibited: longer duration between the onset of first symptoms and IE diagnosis (P = 0.02); and more frequently: weight loss (P = 0.017) and renal impairment (P = 0.08), lower levels of C-reactive protein (P = 0.0009) and serum albumin (P = 0.0032), involvement of both aortic and mitral valves (P = 0.009), and longer hospital stay (P = 0.016). Under multivariate analysis, significant factors for ANCA-associated IE were: longer hospital stay (P = 0.004), lower level of serum albumin (P = 0.02), and multiple valve involvement (P = 0.04). Mortality rate was 25% in ANCA patients; death was because of IE complications in all these patients.Our study identifies a high prevalence of ANCA in unselected patients with IE in internal medicine (24%). Our findings further underscore that ANCA may be associated with a subacute form of IE leading to multiple valve involvement and more frequent renal impairment. Because death was due to IE complications in all patients, our data suggest that aggressive therapy may be required to improve such patients' outcome.
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Registered trials
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