ArticleScientific reports2016
Ligand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite Varroa destructor.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- Neuropeptide natalisin regulates reproductive behaviors in Spodoptera frugiperda.Scientific reports · 2024Article
- Bee-safe peptidomimetic acaricides achieved by comparative genomics.Scientific reports · 2022Article
- Bacterial-mediated RNAi and functional analysis of Natalisin in a moth.Scientific reports · 2021Article
- Enlisting thePathogens (Basel, Switzerland) · 2021Article
- Functional Characterization of Ecdysis Triggering Hormone Receptors (AgETHR-A and AgETHR-B) in the African Malaria Mosquito,Frontiers in physiology · 2021Article
- Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.Frontiers in neuroscience · 2019Review
- Function of the natalisin receptor in mating of the oriental fruit fly, Bactrocera dorsalis (Hendel) and testing of peptidomimetics.PloS one · 2018Article
- Characterization of a β-Adrenergic-Like Octopamine Receptor in the Oriental Fruit Fly, Bactrocera dorsalis (Hendel).International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The varroa mite, Varroa destructor, is a devastating ectoparasite of the honey bees Apis mellifera and A. cerana. Control of these mites in beehives is a challenge in part due to the lack of toxic agents that are specific to mites and not to the host honey bee. In searching for a specific toxic target of varroa mites, we investigated two closely related neuropeptidergic systems, tachykinin-related peptide (TRP) and natalisin (NTL), and their respective receptors. Honey bees lack both NTL and the NTL receptor in their genome sequences, providing the rationale for investigating these receptors to understand their specificities to various ligands. We characterized the receptors for NTL and TRP of V. destructor (VdNTL-R and VdTRP-R, respectively) and for TRP of A. mellifera (AmTRP-R) in a heterologous reporter assay system to determine the activities of various ligands including TRP/NTL peptides and peptidomimetics. Although we found that AmTRP-R is highly promiscuous, activated by various ligands including two VdNTL peptides when a total of 36 ligands were tested, we serendipitously found that peptides carrying the C-terminal motif -FWxxRamide are highly specific to VdTRP-R. This motif can serve as a seed sequence for designing a VdTRP-R-specific agonist.
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