ArticleMicrobiologyOpen2016
Oscillating behavior of Clostridium difficile Min proteins in Bacillus subtilis.
Article in MicrobiologyOpen, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Defining the order of assembly of theJournal of bacteriology · 2026Article
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- Defining the order of assembly of thebioRxiv : the preprint server for biology · 2026Article
- Phase variation of Clostridioides difficile colony morphology occurs via modulation of cell division.PLoS pathogens · 2025Article
- Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024Review
- Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA.International journal of molecular sciences · 2021Article
- The E. coli MinCDE system in the regulation of protein patterns and gradients.Cellular and molecular life sciences : CMLS · 2019Review
- A Strongly Fluorescing Anaerobic Reporter and Protein-Tagging System forApplied and environmental microbiology · 2019Article
- The Min-protein oscillations inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Bacterial Cell Division: Nonmodels Poised to Take the Spotlight.Annual review of microbiology · 2017Review
- Article
- Multistability and dynamic transitions of intracellular Min protein patterns.Molecular systems biology · 2016Article
- Oscillating behavior of Clostridium difficile Min proteins in Bacillus subtilis.MicrobiologyOpen · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In rod-shaped bacteria, the proper placement of the division septum at the midcell relies, at least partially, on the proteins of the Min system as an inhibitor of cell division. The main principle of Min system function involves the formation of an inhibitor gradient along the cell axis; however, the establishment of this gradient differs between two well-studied gram-negative and gram-positive bacteria. While in gram-negative Escherichia coli, the Min system undergoes pole-to-pole oscillation, in gram-positive Bacillus subtilis, proper spatial inhibition is achieved by the preferential attraction of the Min proteins to the cell poles. Nevertheless, when E.coli Min proteins are inserted into B.subtilis cells, they still oscillate, which negatively affects asymmetric septation during sporulation in this organism. Interestingly, homologs of both Min systems were found to be present in various combinations in the genomes of anaerobic and endospore-forming Clostridia, including the pathogenic Clostridium difficile. Here, we have investigated the localization and behavior of C.difficile Min protein homologs and showed that MinDE proteins of C.difficile can oscillate when expressed together in B.subtilis cells. We have also investigated the effects of this oscillation on B.subtilis sporulation, and observed decreased sporulation efficiency in strains harboring the MinDE genes. Additionally, we have evaluated the effects of C.difficile Min protein expression on vegetative division in this heterologous host.
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