Evidence map›Paper›PMID 26817639›Full record

Trial reportBMJ open2016

School-based intervention for the prevention of HPV among adolescents: a cluster randomised controlled study.

Maria Grandahl, Andreas Rosenblad, Christina Stenhammar, Tanja Tydén, Ragnar Westerling, Margareta Larsson, Marie Oscarsson, Bengt Andrae, Tina Dalianis, Tryggve Nevéus

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02280967 (Prevention of Human Papillomavirus), which is not on this map. Cited by 67 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 8 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02280967 nacompletednot on this map

Prevention of Human Papillomavirus (HPV) Associated Cancer by Intervention Studies in Teenagers Attending School Health

TypeinterventionalSponsorUppsala UniversityRan2014 to 2017Enrolled832ConditionsHuman Papillomavirus, Cervix CancerArmsEducation about HPV by school nurse
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 8 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  6. Increasing HPV Vaccination Uptake among Adolescents: A Systematic Review.International journal of environmental research and public health · 2020
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  7. Improving vaccination uptake among adolescents.The Cochrane database of systematic reviews · 2020
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Maria GrandahlDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Andreas RosenbladCentre for Clinical Research Västerås, Uppsala University, Västerås, Sweden.
Christina StenhammarDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Tanja TydénDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Ragnar WesterlingDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Margareta LarssonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Marie OscarssonDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden Department of Health and Caring Sciences, Linnaeus University, Kalmar, Sweden.
Bengt AndraeCentre for Research and Development, Uppsala University/Region of Gävleborg, Gävle, Sweden.
Tina DalianisDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Tryggve NevéusDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Uppsala University · SEKarolinska University Hospital · SELinnaeus University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo improve primary prevention of human papillomavirus (HPV) infection by promoting vaccination and increased condom use among upper secondary school students.

designCluster randomised controlled trial.

setting18 upper secondary schools in Sweden.

participantsSchools were first randomised to the intervention or the control group, after which individual classes were randomised so as to be included or not. Of the 832 students aged 16 years invited to participate during the regular individual health interview with the school nurse, 751 (90.2%) agreed to participate and 741 (89.1%) students completed the study.

interventionsThe intervention was based on the Health Belief Model (HBM). According to HBM, a person's health behaviour can be explained by individual beliefs regarding health actions. School nurses delivered 30 min face-to-face structured information about HPV, including cancer risks and HPV prevention, by propagating condom use and HPV vaccination. Students in the intervention and the control groups completed questionnaires at baseline and after 3 months.

main outcome measuresIntention to use condom with a new partner and beliefs about primary prevention of HPV, and also specifically vaccination status and increased condom use.

resultsAll statistical analyses were performed at the individual level. The intervention had a significant effect on the intention to use condom (p=0.004). There was also a significant effect on HBM total score (p=0.003), with a 2.559 points higher score for the intervention group compared to the controls. The influence on the HBM parameters susceptibility and severity was also significant (p<0.001 for both variables). The intervention also influenced behaviour: girls in the intervention group chose to have themselves vaccinated to a significantly higher degree than the controls (p=0.02). No harms were reported.

conclusionsThe school-based intervention had favourable effects on the beliefs about primary prevention of HPV, and increased the HPV vaccination rates in a diverse population of adolescents. TRIAL REGISTRATION NUMBER: NCT02280967; Results.

Indexed as

Papillomavirus VaccinesSchool Health ServicesAdolescentAdolescent BehaviorCondomsFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHealth PromotionHumansIntentionMaleOutcome Assessment, Health CarePapillomavirus InfectionsSafe SexSchoolsPapillomavirus VaccinesadolescentsHPVpreventionrandomised control trialschool-based

Identifiers

PMID26817639
PMCPMC4735203
OpenAlexW1836258089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.