Evidence map›Paper›PMID 26817624›Full record

Trial reportAnnals of surgery2016

The Important Role for Intravenous Iron in Perioperative Patient Blood Management in Major Abdominal Surgery: A Randomized Controlled Trial.

Bernd Froessler, Peter Palm, Ingo Weber, Nicolette A Hodyl, Rajvinder Singh, Elizabeth M Murphy

4 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 129 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03500497 completednot on this mapstarted 2017, after this paper: background citation

The Change in RetHe - Levels Perioperatively in a Cohort of Colorectal Surgery Patient: it's Role in Perioperative Hemoglobin Optimization

TypeobservationalSponsorMaastricht University Medical CenterRan2017 to 2019Enrolled164ConditionsAnemia, Colorectal Surgery, PerioperativeArmsRetHe measurement (Sysmex)
NCT04083755 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With Lower Extremity Peripheral Artery Disease

TypeinterventionalSponsorBiobizkaia Health Research InstituteRan2019 to 2025Enrolled240ConditionsAnemia, Peripheral Arterial Occlusive DiseaseArmsFerric Carboxymaltose Injection [Injectafer], no treatment or oral iron supplementation
NCT05505006 phase4unknown statusnot on this mapstarted 2021, after this paper: background citation

Management of Preoperative Anaemia in Surgical Oncology as a Tool to Reduce Blood Transfusion Need

TypeinterventionalSponsorAzienda Ospedaliera Universitaria Integrata VeronaRan2021 to 2024Enrolled500ConditionsAnemia, TumorArmsFerric Carboxymaltose Injection, Folic acid, B12
NCT06366698 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

Randomized Control Trial: Intravenous Iron Versus Oral Iron for the Treatment of Iron Deficiency Anemia in Pregnancy

TypeinterventionalSponsorArrowhead Regional Medical CenterRan2023 to 2025Enrolled900ConditionsIron Deficiency Anemia of PregnancyArmsVenofer 200 MG Per 10 ML Injection, Ferrous sulfate
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Preoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: a systematic review and meta-analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Intravenous iron therapy for non-anaemic, iron-deficient adults.The Cochrane database of systematic reviews · 2019
    Pooled it
  13. Iron therapy for preoperative anaemia.The Cochrane database of systematic reviews · 2019
    Pooled it
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Article
  20. Article

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bernd Froessler*Department of Anaesthesia, Lyell McEwin Hospital, South Australia, Australia†Discipline of Acute Care Medicine, University of Adelaide, South Australia, Australia‡The Robinson Research Institute, School of Medicine, University of Adelaide, South Australia, Australia§Department of Gastroenterology, Lyell McEwin Hospital, South Australia, Australia¶Discipline of Medicine, University of Adelaide, South Australia, Australia||Lyell McEwin Hospital, South Australia, Australia.
Peter Palm
Ingo Weber
Nicolette A Hodyl
Rajvinder Singh
Elizabeth M Murphy

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine if preoperative intravenous (IV) iron improves outcomes in abdominal surgery patients. SUMMARY BACKGROUND DATA: Preoperative iron deficiency anemia (IDA) occurs frequently; however if left untreated, increases the risk of blood transfusion allogeneic blood transfusion (ABT). Limited evidence supports IDA treatment with preoperative IV iron. This randomized controlled trial aimed to determine whether perioperative IV iron reduced the need for ABT.

methodsBetween August 2011 and November 2014, 72 patients with IDA were assigned to receive either IV iron or usual care. The primary endpoint was incidence of ABT. Secondary endpoints were various hemoglobin (Hb) levels, change in Hb between time points, length of stay, iron status, morbidity, mortality, and quality of life 4 weeks postsurgery.

resultsA 60% reduction in ABT was observed in the IV iron group compared with the usual care group (31.25% vs 12.5%). Hb values, although similar at randomization, improved by 0.8 g/dL with IV iron compared with 0.1 g/dL with usual care (P = 0.01) by the day of admission. The IV iron group had higher Hb 4 weeks after discharge compared with the usual care group (1.9 vs 0.9 g/dL, P = 0.01), and a shorter length of stay (7.0 vs 9.7 d, P = 0.026). There was no difference in discharge Hb levels, morbidity, mortality, or quality of life.

conclusionsAdministration of perioperative IV iron reduces the need for blood transfusion, and is associated with a shorter hospital stay, enhanced restoration of iron stores, and a higher mean Hb concentration 4 weeks after surgery.

Indexed as

Length of StayPerioperative CarePostoperative CareQuality of LifeAbdominal CavityAgedAnemia, Iron-DeficiencyBlood Loss, SurgicalBlood TransfusionBody Mass IndexDigestive System Surgical ProceduresFemaleFerric CompoundsFollow-Up StudiesHumansInjections, Intravenousferric carboxymaltoseFerric CompoundsMaltose

Identifiers

PMID26817624
PMCPMC4902320

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.