Trial reportDrug and alcohol dependence2016
A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence.
Trial report in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Psychosocial interventions for stimulant use disorder.The Cochrane database of systematic reviews · 2024Pooled it
- Disulfiram for the treatment of cocaine dependence.The Cochrane database of systematic reviews · 2024Pooled it
- Comparison of Treatments for Cocaine Use Disorder Among Adults: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Pharmacotherapy for Cocaine Use Disorder-a Systematic Review and Meta-analysis.Journal of general internal medicine · 2019Pooled it
- Change in employment status and cocaine use treatment outcomes: A secondary analysis across six clinical trials.Journal of substance abuse treatment · 2019Pooled it
- Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race.Journal of substance abuse treatment · 2019Pooled it
- Comparative efficacy and acceptability of psychosocial interventions for individuals with cocaine and amphetamine addiction: A systematic review and network meta-analysis.PLoS medicine · 2018Pooled it
- Longitudinal changes in network engagement during cognitive control in cocaine use disorder.Drug and alcohol dependence · 2021Trial
- Functional neural changes following behavioral therapies and disulfiram for cocaine dependence.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017Trial
- Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder.Journal of substance abuse treatment · 2017Trial
- Smokers versus snorters: do treatment outcomes differ according to route of cocaine administration?Experimental and clinical psychopharmacology · 2013Trial
- Testing measurement invariance of the Brief Symptom Inventory across race, sex, and time among adults with cocaine use disorder.Psychological assessment · 2026Article
- Cocaine Use Disorder: Neuropathology and Exploratory Treatments.Molecular neurobiology · 2026Review
- Disruption of Dopamine Homeostasis by Psychostimulants.Molecular neurobiology · 2026Review
- The Unsolved Problem of Attrition Rates on Randomized Clinical Trials for Cocaine Use Disorders: A Scoping Review.Substance use & addiction journal · 2025Article
- Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes.Journal of substance use and addiction treatment · 2024Article
- Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use.Drug and alcohol dependence · 2023Article
- Exploring the performance of during-treatment substance use outcome measures in predicting longer-term psychosocial functioning and post-treatment abstinence.Drug and alcohol dependence · 2023Article
- Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory.Drug and alcohol dependence · 2021Article
- Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice.Psychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThis study evaluated the extent to which the addition of disulfiram and contingency management for adherence and abstinence (CM), alone and in combination, might enhance the effects of cognitive behavioral therapy (CBT) for cocaine use disorders.
methodsFactorial randomized double blind (for medication condition) clinical trial where CBT served as the platform and was delivered in weekly individual sessions in a community-based outpatient clinic. 99 outpatients who met DSM-IV criteria for current cocaine dependence were assigned to receive either disulfiram or placebo, and either CM or no CM. Cocaine and other substance use was assessed via a daily calendar with thrice weekly urine sample testing for 12 weeks with a one-year follow-up (80% interviewed at one year).
resultsThe primary hypothesis that CM and disulfiram would produce the best cocaine outcomes was not confirmed, nor was there a main effect for disulfiram. For the primary outcome (percent days of abstinence, self report), there was a significant interaction, with the best cocaine outcomes were seen for the combination of CM and placebo, with the two groups assigned to disulfiram associated with intermediate outcomes, and poorest cocaine outcome among those assigned to placebo and no CM. The secondary outcome (urinalysis) indicated a significant effect favoring CM over no CM but the interaction effect was not significant. One year follow-up data indicated sustained treatment effects across conditions.
conclusionsCM enhances outcomes for CBT treatment of cocaine dependence, but disulfiram provided no added benefit to the combination of CM and CBT.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.