ArticleJournal of cardiovascular computed tomography
Total coronary atherosclerotic plaque burden assessment by CT angiography for detecting obstructive coronary artery disease associated with myocardial perfusion abnormalities.
Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of a Tai Chi rehabilitation program implemented using a hybrid online and offline mode on oxidative stress and inflammatory responses in patients with coronary heart disease: a randomized controlled trial.Frontiers in public health · 2024Trial
- Atherosclerotic coronary plaque regression from lipid-lowering therapies: A meta-analysis and meta-regression.American journal of preventive cardiology · 2024Article
- Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography.European heart journal · 2024Review
- High-quality annotations for deep learning enabled plaque analysis in SCAPIS cardiac computed tomography angiography.Heliyon · 2023Article
- m6A regulator-mediated RNA methylation modification patterns are involved in the regulation of the immune microenvironment in ischaemic cardiomyopathy.Scientific reports · 2023Article
- Identifying patterns of immune related cells and genes in the peripheral blood of acute myocardial infarction patients using a small cohort.Journal of translational medicine · 2022Article
- Article
- Coronary artery disease imaging reporting and data system (CAD-RADS): what radiologists need to know?Emergency radiology · 2021Review
- From CT to artificial intelligence for complex assessment of plaque-associated risk.The international journal of cardiovascular imaging · 2020Review
- Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events.The international journal of cardiovascular imaging · 2020Article
- Article
- Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE 320 Multinational Study.Journal of the American Heart Association · 2019Article
- Coronary computed tomography angiography: a method coming of age.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Review
- 64-Slice spiral double-low CT to evaluate the degree of stenosis and plaque composition in diagnosing coronary artery disease.Experimental and therapeutic medicine · 2017Article
- The Role of Imaging in Cardiovascular Prevention: A Comprehensive Review.Journal of cardiovascular echographyReview
- Endothelial shear stress computed from coronary computed tomography angiography: A direct comparison to intravascular ultrasound.Journal of cardiovascular computed tomographyArticle
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Authors and funding
20 authors at 11 institutions in 5 countries.
Funding
Abstract
backgroundTotal atherosclerotic plaque burden assessment by CT angiography (CTA) is a promising tool for diagnosis and prognosis of coronary artery disease (CAD) but its validation is restricted to small clinical studies. We tested the feasibility of semi-automatically derived coronary atheroma burden assessment for identifying patients with hemodynamically significant CAD in a large cohort of patients with heterogenous characteristics.
methodsThis study focused on the CTA component of the CORE320 study population. A semi-automated contour detection algorithm quantified total coronary atheroma volume defined as the difference between vessel and lumen volume. Percent atheroma volume (PAV = [total atheroma volume/total vessel volume] × 100) was the primary metric for assessment (n = 374). The area under the receiver operating characteristic curve (AUC) determined the diagnostic accuracy for identifying patients with hemodynamically significant CAD defined as ≥50% stenosis by quantitative coronary angiography and associated myocardial perfusion abnormality by SPECT.
resultsOf 374 patients, 139 (37%) had hemodynamically significant CAD. The AUC for PAV was 0.78 (95% confidence interval [CI] 0.73-0.83) compared with 0.84 [0.79-0.88] by standard expert CTA interpretation (p = 0.02). Accuracy for both CTA (0.91 [0.87, 0.96]) and PAV (0.86 [0.81-0.91]) increased after excluding patients with history of CAD (p < 0.01 for both). Bland-Altman analysis revealed good agreement between two observers (bias of 280.2 mm(3) [161.8, 398.7]).
conclusionsA semi-automatically derived index of total coronary atheroma volume yields good accuracy for identifying patients with hemodynamically significant CAD, though marginally inferior to CTA expert reading. These results convey promise for rapid, reliable evaluation of clinically relevant CAD.
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