ArticleJournal of clinical and diagnostic research : JCDR2015
Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches.International journal of oral science · 2024Review
- Review
- Oral Health and Risk of Retinal Vascular Occlusions: A Nationwide Cohort Study.Journal of personalized medicine · 2023Article
- The Influence of Propolis on Dental Plaque Reduction and the Correlation between Dental Plaque and Severity of COVID-19 Complications-A Literature Review.Molecules (Basel, Switzerland) · 2021Review
- Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages.Healthcare (Basel, Switzerland) · 2021Article
- Oral manifestations in coronavirus disease 2019 (COVID-19).Oral diseases · 2021Article
- Characteristics of Oral Manifestations in Symptomatic Non-Hospitalized COVID-19 Patients: A Cross-Sectional Study on a Sample of the Saudi Population.International journal of general medicine · 2021Article
- Blood Levels of Glycated Hemoglobin, D-Dimer, and Fibrinogen in Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Hypercoagulability in COVID-19: A review of the potential mechanisms underlying clotting disorders.SAGE open medicine · 2021Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFibrinogen degradation products (e.g. D-dimer) arise from digested fibrin clots and fibrinogen. Elevated concentrations accompany activation of coagulation and fibrinolysis and indicate chronic inflammatory diseases. D-Dimer tests are a quick, noninvasive method to rule out abnormal clotting. Periodontitis strongly affects the haemostatic system and evokes a procoagulant state. Correlation of chronic periodontitis with early indicators of disease (biomarkers) might be useful.
aimThe aim of the study was to examine whether the plasma D-dimer concentration reflects the progression of chronic periodontitis and the beneficial effect of periodontal therapy. MATERIALS AND
methodsForty randomly selected subjects were divided into four groups, Group I: 10 healthy subjects, Group II: 10 with mild periodontitis, Group III: 10 with moderate periodontitis, Group IV: 10 with severe periodontitis. After thorough dental and periodontal examination, 3 mL of venous blood was collected for measurement of fibrinogen degradation products.
resultsThe patients with moderate and chronic periodontitis exhibited high concentrations of D-dimer (mean value 434.98-535.52 mcg/mL), whereas subjects with mild or no periodontitis exhibited values of 329.78-211.29 mcg/mL. Concentrations of D-dimer were significantly reduced after therapy of all classes of periodontitis.
conclusionPeriodontal treatment can reduce amount of D-dimer in the plasma. A higher than normal concentration is observed in chronic periodontitis.
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