Evidence map›Paper›PMID 26816589›Full record

ArticleElectronic physician2015

Occult Hepatitis C Virus Infection in Hemodialysis Patients; Single Center Study.

Samya El-Shishtawy, Nevine Sherif, Emad Abdallh, Laila Kamel, Mohamed Shemis, Abdel Aziz Ali Saleem, Haitham Abdalla, Hesham Gamal El Din

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electronic physician, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. [Current status of the prevalence, diagnosis, and treatment of hepatitis C in patients undergoing hemodialysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Samya El-ShishtawyNephrology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Nevine SherifNephrology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Emad AbdallhNephrology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Laila KamelClinical Pathology Department Theodor Bilharz Research Institute, Giza, Egypt.
Mohamed ShemisBiochemistry Department, Theodor Bilharz Research Institute, Giza, Egypt.
Abdel Aziz Ali SaleemDepartment of Tropical Diseases, Theodor Bilharz Research Institute, Giza, Egypt.
Haitham AbdallaDepartment of Tropical Diseases, Theodor Bilharz Research Institute, Giza, Egypt.
Hesham Gamal El DinClinical Pathology Department National Research Center, Giza, Egypt.
Theodor Bilharz Research Institute · EGNational Water Research Center · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA new form of hepatitis C virus infection, known as occult hepatitis C virus (HCV) infection, is characterized by the presence of HCV_RNA in the liver or peripheral blood mononuclear cells (PBMCs). However, no serological markers of infection occur and there is not as much damage to the liver damage as is produced by chronic hepatitis C. There is a high incidence of HCV infection among hemodialysis patients, there is significant concern about viral transmission. HCV infection is a major problem in hemodialysis (HD) units even though blood products are screened for anti-HCV antibodies and other precautions are taken. The aim of this study was to determine the prevalence of occult HCV infection in PBMC in chronic hemodialysis (CHD) patients in the dialysis unit at Theodor Bilharz Research Institute (TBRI) with HCV antibodies and HCV RNA negativity irrespective of their liver function tests.

methodsFifty-three patients who were repeatedly were anti-HCV negative and serum HCV-RNA negative and on regular hemodialysis for > six months were enrolled in the study, which was conducted in the dialysis unit of Nephrology Department at TBRI; there were 10 healthy matched controls. The patients were classified into two groups according to the result HCV RNA in their PBMCs. Serological markers of HCV infection, including anti-HCV antibody and serum HCV-RNA, were repeatedly negative for all patients included in the study. We collected serum and PBMC samples from the patients on the day they entered the study. The test of all serum samples for anti-HCV antibodies and HCV-RNA was repeated by RT-PCR to ensure that the patients did not have these HCV serologic markers, We also measured their ALT and GGT levels.

resultsOccult hepatitis C virus infection (OCI) was detected in 15.1% of our CHD patients without any evidence of chronic liver disease.

conclusionOccult HCV infection was present among the hemodialysis patients irrespective of whether they had persistent abnormal values of liver enzymes for which no cause had been identified. Further study is required to determine the clinical significance of occult HCV infections in these patients.

Indexed as

hemodialysishepatitis Coccult infection

Identifiers

PMID26816589
PMCPMC4725416
OpenAlexW2396431677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.