ReviewFrontiers in zoology2015
Paternal early experiences influence infant development through non-social mechanisms in Rhesus Macaques.
Review in Frontiers in zoology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Early Life Stress and Adversity in Children: Neuroendocrine Mechanisms, Epigenetic Regulation, and Lifespan Developmental Outcomes-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Stress (Amsterdam, Netherlands) · 2024Article
- Survival rates and mortality risks of Plecturocebus cupreus at the California National Primate Research Center.American journal of primatology · 2023Article
- Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals.Neuroscience and biobehavioral reviews · 2023Review
- Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques' exposure to wildfire smoke.Nature communications · 2022Article
- Profiling nonhuman primate germline RNA to understand the legacy of early life stress.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center.Animals : an open access journal from MDPI · 2021Review
- Update on the neurodevelopmental theory of depression: is there any 'unconscious code'?Pharmacological reports : PR · 2021Review
- Rearing condition may alter neonatal development of captive Bolivian squirrel monkeys (Saimiri boliviensis boliviensis).Developmental psychobiology · 2020Article
- Immune to happiness - inflammatory process indicators and depressive personality traits.Archives of medical science : AMS · 2020Article
- Multilevel Impact of Prenatal Risk and Protective Factors on Stress Biology and Infant Development: Study protocol of BABIP prospective birth cohort from Turkey.Brain, behavior, & immunity - health · 2020Article
- Disentangling the effects of early caregiving experience and heritable factors on brain white matter development in rhesus monkeys.NeuroImage · 2019Article
- Mothers, Fathers, and Others: Neural Substrates of Parental Care.Trends in neurosciences · 2019Review
- The neural mechanisms and consequences of paternal caregiving.Nature reviews. Neuroscience · 2019Review
- Article
- Parenting in Animals.Current opinion in psychology · 2017Article
- Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.Zoological research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly experiences influence the developing organism, with lifelong and potentially adaptive consequences. It has recently become clear that the effects of early experiences are not limited to the exposed generation, but can influence physiological and behavioral traits in the next generation. Mechanisms of transgenerational effects of parental early experiences on offspring development are often attributed to prenatal or postnatal parental influence, but recent data suggest that germ-line plasticity may also play a role in the transgenerational effects of early experiences. These non-genetic transgenerational effects are a potentially important developmental and evolutionary force, but the effects of parental experiences on behavior and physiology are not well understood in socially complex primates. In the non-human primate, the rhesus macaque, nursery rearing (NR) is an early life manipulation used for colony management purposes, and involves separating infants from parents early in life. We examined the effects of maternal and paternal early NR on infant rhesus macaque immunity, physiology, and behavior.
resultsWe theorized that differences in behavior or physiology in the absence of parent-offspring social contact would point to biological and perhaps germ-line, rather than social, mechanisms of effect. Thus, all subjects were themselves NR. Male and female infant rhesus macaques (N= 206) were separated from parents and social groups in the first four days of life to undergo NR. These infants differed only in their degree of NR ancestry - whether their dams or sires were themselves NR. At 3-4 months of age, infants underwent a standardized biobehavioral assessment. Factors describing immunity, plasma cortisol, and emotion regulation were generated from these data using factor analysis. Paternal, but not maternal, NR was associated with greater emotionality and higher plasma cortisol, compared with infants born to CONTROL reared fathers.
conclusionsThese data suggest that macaque biobehavioral makeup is strongly influenced by paternal experiences, and via non-social mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.