ArticleJournal of pharmacology & pharmacotherapeutics
A case of losartan-induced severe hyponatremia.
Article in Journal of pharmacology & pharmacotherapeutics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Drug-Induced Hyponatremia: Insights into Pharmacological Mechanisms and Clinical Practice Management.Journal of clinical medicine · 2025Review
- Laboratory medicine in arterial hypertension.Biochemia medica · 2023Review
- The Incidence and Risk Factors of Hyponatremia in Pulmonary Tuberculosis.Journal of the Endocrine Society · 2022Article
- Clinical predictors of hyponatremia in patients with heart failure according to severity of chronic kidney disease.Wiener klinische Wochenschrift · 2022Article
- Severe hyponatremia due to trimethoprim-sulfamethoxazole-induced SIADH.SAGE open medical case reports · 2022Article
- Associations Between Antihypertensive Medications and Severe Hyponatremia: A Swedish Population-Based Case-Control Study.The Journal of clinical endocrinology and metabolism · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case report outlines a very rare case of losartan-induced severe hyponatremia in a 73-year-old type 2 diabetic patient. The patient was initiated with 50 mg daily oral losartan monotherapy for newly diagnosed moderate hypertension. After 3.5 months of taking the drug, he presented to the emergency department in a drowsy state with severe generalized weakness and occasional palpitations. He was a known diabetic for the last 3 years and well controlled by oral metformin alone. On examination, his serum sodium level was found to be 123 meq/L. There were no evidences of any other possible metabolic, infective, organic or other pathologic causes giving rise to that condition, except losartan itself. De-challenge was done and he was treated vigorously resulting in reversal of the diseased state. Naranjo adverse drug reaction probability scale suggested that it was "probable" that oral losartan was responsible for the development of severe hyponatremia in this patient.
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