ArticleEuropean journal of nuclear medicine and molecular imaging2016
Quantitative assessment of atherosclerotic plaques on (18)F-FDG PET/MRI: comparison with a PET/CT hybrid system.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2018Pooled it
- PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.Stroke · 2026Review
- In Vivo Classification and Characterization of Carotid Atherosclerotic Lesions with IntegratedDiagnostics (Basel, Switzerland) · 2024Article
- Induction of Arterial Inflammation by Immune Checkpoint Inhibitor Therapy in Lung Cancer Patients as Measured by 2-[Life (Basel, Switzerland) · 2024Article
- Morphological feature and mapping inflammation in classified carotid plaques in symptomatic and asymptomatic patients: A hybridFrontiers in neuroscience · 2023Article
- Hybrid positron emission tomography and magnetic resonance imaging in carotid atherosclerosis: Not ready for prime time?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Observational
- Imaging Inflammation in Atherosclerosis with CXCR4-Directed [Life (Basel, Switzerland) · 2022Article
- Accuracy of PET quantification in [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- MUW researcher of the month.Wiener klinische Wochenschrift · 2021Article
- Article
- Integrated cardiovascular assessment of atherosclerosis using PET/MRI.The British journal of radiology · 2020Review
- PET/MRI of atherosclerosis.Cardiovascular diagnosis and therapy · 2020Review
- Whole-Body Atherosclerosis Imaging by Positron Emission Tomography/Magnetic Resonance Imaging: From Mice to Nonhuman Primates.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- [European journal of nuclear medicine and molecular imaging · 2019Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Partial volume correction for improved PET quantification inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- [68Ga]Pentixafor-PET/MRI for the detection of Chemokine receptor 4 expression in atherosclerotic plaques.European journal of nuclear medicine and molecular imaging · 2018Article
- MR/PET Imaging of the Cardiovascular System.JACC. Cardiovascular imaging · 2017Review
- Cardiac Applications of PET-MR.Current cardiology reports · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePET with (18)F-FDG has the potential to assess vascular macrophage metabolism. (18)F-FDG is most often used in combination with contrast-enhanced CT to localize increased metabolism to specific arterial lesions. Novel (18)F-FDG PET/MRI hybrid imaging shows high potential for the combined evaluation of atherosclerotic plaques, due to the superior morphological conspicuity of plaque lesions. The purpose of this study was to evaluate the reliability and accuracy of (18)F-FDG PET/MRI uptake quantification compared to PET/CT as a reference standard in patients with carotid atherosclerotic plaques.
methodsThe study group comprised 34 consecutive oncological patients with carotid plaques who underwent both PET/CT and PET/MRI with (18)F-FDG on the same day. The presence of atherosclerotic plaques was confirmed by 3 T MRI scans. Maximum standardized uptake values (SUVmax) for carotid plaque lesions and the average SUV of the blood pool within the adjacent internal jugular vein were determined and target-to-blood ratios (TBRs, plaque to blood pool) were calculated.
resultsAtherosclerotic lesions with maximum colocalized focal FDG uptake were assessed in each patient. SUVmax values of carotid plaque lesions were significantly lower on PET/MRI than on PET/CT (2.3 ± 0.6 vs. 3.1 ± 0.6; P < 0.01), but were significantly correlated between PET/CT and PET/MRI (Spearman's r = 0.67, P < 0.01). In contrast, TBRmax values of plaque lesions were similar on PET/MRI and on PET/CT (2.2 ± 0.3 vs. 2.2 ± 0.3; P = 0.4), and again were significantly correlated between PET/MRI and PET/CT (Spearman's r = 0.73, P < 0.01). Considering the increasing trend in SUVmax and TBRmax values from early to delayed imaging time-points on PET/CT and PET/MRI, respectively, with continuous clearance of radioactivity from the blood, a slight underestimation of TBRmax values may also be expected with PET/MRI compared with PET/CT.
conclusionSUVmax and TBRmax values are widely accepted reference parameters for estimation of the radioactivity of atherosclerotic plaques on PET/CT. However, due to a systematic underestimation of SUVmax and TBRmax with PET/MRI, the optimal cut-off values indicating the presence of inflamed plaque tissue need to be newly defined for PET/MRI.
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