ArticleEuropean journal of nuclear medicine and molecular imaging2016
Reduction in camera-specific variability in [(123)I]FP-CIT SPECT outcome measures by image reconstruction optimized for multisite settings: impact on age-dependence of the specific binding ratio in the ENC-DAT database of healthy controls.
Article in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0.European journal of nuclear medicine and molecular imaging · 2020Guideline
- Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.European journal of nuclear medicine and molecular imaging · 2025Article
- Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitativeJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Quantitative evaluation of striatal uptake ratios using an adaptive template registration method forAnnals of nuclear medicine · 2024Article
- Harmonizing multisite data with the ComBat method for enhanced Parkinson's disease diagnosis via DAT-SPECT.Frontiers in neurology · 2024Article
- Neuronal Loss in the Bilateral Medial Frontal Lobe Revealed byNeurologia medico-chirurgica · 2023Article
- Semi-quantitative analysis of visually normalEJNMMI research · 2023Article
- Impact of age and sex correction on the diagnostic performance of dopamine transporter SPECT.European journal of nuclear medicine and molecular imaging · 2021Article
- Preserved ExtrastriatalMolecular imaging and biology · 2020Article
- Impact of the size of the normal database on the performance of the specific binding ratio in dopamine transporter SPECT.EJNMMI physics · 2020Article
- Single-siteEuropean journal of hybrid imaging · 2020Article
- Automatic classification of dopamine transporter SPECT: deep convolutional neural networks can be trained to be robust with respect to variable image characteristics.European journal of nuclear medicine and molecular imaging · 2019Article
- Diagnostic performance of the specific uptake size index for semi-quantitative analysis of I-123-FP-CIT SPECT: harmonized multi-center research setting versus typical clinical single-camera setting.EJNMMI research · 2019Article
- Quantitative Intensity Harmonization of Dopamine Transporter SPECT Images Using Gamma Mixture Models.Molecular imaging and biology · 2019Article
- Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis.Annals of nuclear medicine · 2019Article
- Impact of quantitative index derived from 123I-FP-CIT-SPECT on reconstruction with correction methods evaluated using a 3D-striatum digital brain phantom.Radiological physics and technology · 2018Article
- The subresolution DaTSCAN phantom: a cost-effective, flexible alternative to traditional phantom technology.Nuclear medicine communications · 2018Article
- Validation of Optimum ROI Size forAsia Oceania journal of nuclear medicine & biology · 2018Article
- The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [EJNMMI research · 2017Article
- [EJNMMI physics · 2017Article
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20 authors.
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Abstract
purposeQuantitative estimates of dopamine transporter availability, determined with [(123)I]FP-CIT SPECT, depend on the SPECT equipment, including both hardware and (reconstruction) software, which limits their use in multicentre research and clinical routine. This study tested a dedicated reconstruction algorithm for its ability to reduce camera-specific intersubject variability in [(123)I]FP-CIT SPECT. The secondary aim was to evaluate binding in whole brain (excluding striatum) as a reference for quantitative analysis.
methodsOf 73 healthy subjects from the European Normal Control Database of [(123)I]FP-CIT recruited at six centres, 70 aged between 20 and 82 years were included. SPECT images were reconstructed using the QSPECT software package which provides fully automated detection of the outer contour of the head, camera-specific correction for scatter and septal penetration by transmission-dependent convolution subtraction, iterative OSEM reconstruction including attenuation correction, and camera-specific "to kBq/ml" calibration. LINK and HERMES reconstruction were used for head-to-head comparison. The specific striatal [(123)I]FP-CIT binding ratio (SBR) was computed using the Southampton method with binding in the whole brain, occipital cortex or cerebellum as the reference. The correlation between SBR and age was used as the primary quality measure.
resultsThe fraction of SBR variability explained by age was highest (1) with QSPECT, independently of the reference region, and (2) with whole brain as the reference, independently of the reconstruction algorithm.
conclusionQSPECT reconstruction appears to be useful for reduction of camera-specific intersubject variability of [(123)I]FP-CIT SPECT in multisite and single-site multicamera settings. Whole brain excluding striatal binding as the reference provides more stable quantitative estimates than occipital or cerebellar binding.
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