Evidence map›Paper›PMID 26816083›Full record

SynthesisJournal of molecular neuroscience : MN2016

Meta-Analysis of the Efficiency and Prognosis of Intracranial Aneurysm Treated with Flow Diverter Devices.

Gengfan Ye, Meng Zhang, Lin Deng, Xiaohui Chen, Yunyan Wang

Abstract readEvaluation StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of molecular neuroscience : MN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Predictors of flow diverter stent in large and giant unruptured intracranial aneurysms, single-center experience.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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  10. Article
  11. Review
  12. Article
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  19. Silk flow-diverter stent for the treatment of complex intracranial aneurysms: A one-year follow-up multicenter study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gengfan YeDepartment of Neurosurgery, Qilu Hospital, Shandong University, No. 107, West Wenhua Road, Jinan, Shandong Province, 250012, China.
Meng ZhangDepartment of Neurosurgery, Qilu Hospital, Shandong University, No. 107, West Wenhua Road, Jinan, Shandong Province, 250012, China.
Lin DengDepartment of Neurosurgery, Qilu Hospital, Shandong University, No. 107, West Wenhua Road, Jinan, Shandong Province, 250012, China.
Xiaohui ChenDepartment of Neurology, Shengli Oilfield Central Hospital, No. 34, Jinan Road, Dongying, Shandong Province, 257034, China.
Yunyan WangDepartment of Neurosurgery, Qilu Hospital, Shandong University, No. 107, West Wenhua Road, Jinan, Shandong Province, 250012, China. wangyunyan0618@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flow diverter devices (FDDs) are increasingly used in the treatment of intracranial aneurysm. The safety and feasibility of FDD were assessed in published literature. In accordance with strict inclusion criteria, Medline, Embase, Cochrane, China National Knowledge Infrastructure, and Web of Science databases were searched for literature that covers a period until February 2015. The baseline characteristics of patients, aneurysms, aneurysm occlusion, morbidity, and mortality were also collected. A meta-analysis was conducted using STATA 12.0, and a chi-squared test was performed to evaluate whether statistically significant differences existed between complications and mortality of aneurysm patients. Finally, a total of 48 studies were selected, including 2508 patients with 2826 aneurysm cases. The mean follow-up interval is 6.3 months, and the aneurysm occlusion rate is 77.9 % (95 % CI 73.8-81.9, I (2) = 43.4 %). The total morbidity and mortality rates are 9.8 and 3.8 %, respectively. The rates of spontaneous rupture and intraparenchymal hemorrhage are 2.0 and 2.5 %, respectively. The rate of ischemic stroke is 5.5 %. The morbidity and mortality rates of giant aneurysms are significantly higher than those of small and large aneurysms (χ (2) = 56.96, p < 0.05; χ (2) = 14.88, p < 0.05). The morbidity rates of posterior aneurysms are significantly higher than those of anterior (χ (2) = 11.29, p < 0.05) and unruptured aneurysms (χ (2) = 10.36, p < 0.05), respectively. The publication bias of aneurysm occlusion was detected by Begg's rank, and the corrected result is less than 0.05. Our meta-analysis suggests that the treatment of intracranial aneurysm with FDD is feasible and effective with a high occlusion rate, acceptable morbidity, and mortality. However, the morbidity or mortality of giant aneurysms is still high.

Indexed as

HumansIntracranial AneurysmIntracranial HemorrhagesNeurosurgical ProceduresPostoperative ComplicationsStentsStrokeFlow diverter devicesIntracranial aneurysmMeta-analysis

Identifiers

PMID26816083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.