Evidence map›Paper›PMID 26815578›Full record

SynthesisPloS one2016

Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis.

Xudong Sun, Yuanyuan Xu, Li Wang, Fuhua Zhang, Jinhua Zhang, Ximei Fu, Tao Jing, Jian Han

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. TLR2 variants andUpsala journal of medical sciences · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Inflammation and Gastric Cancer.Diseases (Basel, Switzerland) · 2022
    Review
  5. Frontiers in medicine · 2020
    Article
  6. Helicobacter pylori infection among patients with liver cirrhosis.European journal of gastroenterology & hepatology · 2017
    Article
  7. Host pathogen interactions inWorld journal of gastroenterology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xudong SunDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Yuanyuan XuDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Li WangDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Fuhua ZhangDepartment of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.
Jinhua ZhangDepartment of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.
Ximei FuDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Tao JingDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Jian HanDepartment of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection.

methodsPublished literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI).

resultsA total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43-0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43-0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44-0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16-1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14-1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup.

conclusionResults of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideHelicobacter InfectionsHelicobacter pyloriHumansTumor Necrosis Factor-alphaTumor Necrosis Factor-alpha

Identifiers

PMID26815578
PMCPMC4729674
OpenAlexW2272922862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.