ArticlePloS one2016
Diffuse Optical Characterization of the Healthy Human Thyroid Tissue and Two Pathological Case Studies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- "hDOS": an automated hybrid diffuse optical device for real-time noninvasive tissue monitoring: precision andJournal of biomedical optics · 2025Article
- Hybrid diffuse optical appraisal of peripheral and cerebral changes in critically ill patients receiving red blood cell transfusion.Biophotonics discovery · 2025Article
- Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies.Biomedical optics express · 2024Article
- How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines.Neurophotonics · 2024Article
- Assessment of power spectral density of microvascular hemodynamics in skeletal muscles at very low and low-frequency via near-infrared diffuse optical spectroscopies.Biomedical optics express · 2023Article
- Transcranial, Non-Invasive Evaluation of Potential Misery Perfusion During Hyperventilation Therapy of Traumatic Brain Injury Patients.Journal of neurotrauma · 2023Article
- Comparison of cerebral metabolic rate of oxygen, blood flow, and bispectral index under general anesthesia.Neurophotonics · 2023Article
- Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus: a proof-of-concept study.Neurophotonics · 2022Article
- Difference imaging from single measurements in diffuse optical tomography: a deep learning approach.Journal of biomedical optics · 2022Article
- Cherenkov light emission in molecular radiation therapy of the thyroid and its application to dosimetry.Biomedical optics express · 2022Article
- Ultrasound segmentation-guided edge artifact reduction in diffuse optical tomography using connected component analysis.Biomedical optics express · 2021Article
- The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening.Biomedical optics express · 2021Article
- Recipes for diffuse correlation spectroscopy instrument design using commonly utilized hardware based on targets for signal-to-noise ratio and precision.Biomedical optics express · 2021Article
- Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements.Biomedical optics express · 2020Article
- Self-calibrating time-resolved near infrared spectroscopy.Biomedical optics express · 2019Article
- Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores.Scientific reports · 2018Article
- Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties.Biomedical optics express · 2018Article
- Time-resolved near infrared light propagation using frequency domain superposition.Biomedical optics express · 2018Article
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9 authors.
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Abstract
The in vivo optical and hemodynamic properties of the healthy (n = 22) and pathological (n = 2) human thyroid tissue were measured non-invasively using a custom time-resolved spectroscopy (TRS) and diffuse correlation spectroscopy (DCS) system. Medical ultrasound was used to guide the placement of the hand-held hybrid optical probe. TRS measured the absorption and reduced scattering coefficients (μa, μs') at three wavelengths (690, 785 and 830 nm) to derive total hemoglobin concentration (THC) and oxygen saturation (StO2). DCS measured the microvascular blood flow index (BFI). Their dependencies on physiological and clinical parameters and positions along the thyroid were investigated and compared to the surrounding sternocleidomastoid muscle. The THC in the thyroid ranged from 131.9 μM to 144.8 μM, showing a 25-44% increase compared to the surrounding sternocleidomastoid muscle tissue. The blood flow was significantly higher in the thyroid (BFIthyroid = 16.0 × 10-9 cm2/s) compared to the muscle (BFImuscle = 7.8 × 10-9 cm2/s), while StO2 showed a small (StO2, muscle = 63.8% to StO2, thyroid = 68.4%), yet significant difference. Two case studies with thyroid nodules underwent the same measurement protocol prior to thyroidectomy. Their THC and BFI reached values around 226.5 μM and 62.8 × 10-9 cm2/s respectively showing a clear contrast to the nodule-free thyroid tissue as well as the general population. The initial characterization of the healthy and pathologic human thyroid tissue lays the ground work for the future investigation on the use of diffuse optics in thyroid cancer screening.
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