Evidence map›Paper›PMID 26815505›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma.

Xiaoying He, Yun Liao, Wen Lu, Gufeng Xu, Huan Tong, Jieqi Ke, Xiaoping Wan

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  7. Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme.Laboratory investigation; a journal of technical methods and pathology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xiaoying HeDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Henshan Road, Xujiahui District, Shanghai, 200030, China.
Yun LiaoDepartment of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, No. 1, Xueshi Road, Hangzhou, Zhejiang, 310006, China.
Wen LuDepartment of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China.
Gufeng XuDepartment of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, No. 1, Xueshi Road, Hangzhou, Zhejiang, 310006, China.
Huan TongDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, 650 New Songjiang Road, Shanghai, 201620, China.
Jieqi KeDepartment of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated First People's Hospital, 650 New Songjiang Road, Shanghai, 201620, China.
Xiaoping WanDepartment of Gynecology, Tongji University School of Medicine Affiliated Shanghai First Maternity and Infant Hospital, No. 2669 Gaoke West Road, Pudong New Area, Shanghai, 200126, China. wanxiaoping@Tongji.edu.cn.
Shanghai First Maternity and Infant Hospital · CNShanghai Jiao Tong University · CNWomen's Hospital, School of Medicine, Zhejiang University · CNInternational Peace Maternity & Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of stathmin (STMN1) is closely linked to tumor metastases and poor prognosis in endometrial carcinoma (EC). However, the underlying mechanism is little known. In the present study, we investigated the expression of STMN1 in EC. Subsequently, we assessed the role of STMN1 in EC cell proliferation and migration. Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis. In vitro, forced expression of STMN1 promoted cell invasion and migration. In contrast, knockdown of STMN1 inhibited cell aggressive behaviors. Moreover, the expression and the activity changes of matrix metalloproteinases (MMP)-2/9 were observed in EC cells after the cells being silenced or overexpression of STMN1. In conclusion, STMN1 is an oncogene and it enhances the growth and invasion of EC possibly by mediating the secretion and activation of MMP2 and MMP9 protein.

Indexed as

Cell MovementCell ProliferationBiomarkers, TumorEndometrial NeoplasmsEndometriumFemaleFollow-Up StudiesHumansImmunoenzyme TechniquesLymphatic MetastasisMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingPrognosisReal-Time Polymerase Chain ReactionBiomarkers, TumorRNA, MessengerStathminSTMN1 protein, humanEndometrial cancerGelatin zymographyMMP2MMP9STMN1

Identifiers

PMID26815505
OpenAlexW2306489075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.