Evidence map›Paper›PMID 26815465›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2011

The Glue Grant experience: characterizing the post injury genomic response.

A G Cuenca, R V Maier, J Cuschieri, E E Moore, L L Moldawer, R G Tompkins, Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Abstract read
In one paragraph

Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The challenges and advances of polytrauma care in 2012.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A G CuencaDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, 32610, USA. alex.cuenca@surgery.ufl.edu.
R V MaierDepartment of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359796, Seattle, WA, 98104-2499, USA. ronmaier@u.washington.edu.
J CuschieriDepartment of Surgery, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359796, Seattle, WA, 98104-2499, USA.
E E MooreDepartment of Surgery, Denver General Hospital and the University of Colorado Health Science Center, Denver, CO, 80262, USA.
L L MoldawerDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
R G TompkinsMassachusetts General Hospital, Harvard Medical School, Boston, MA, 02215, USA.
Inflammation and Host Response to Injury, Large Scale Collaborative Research Program

Funding

Inflammation and the Response to InjuryU54GM062119 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI TOMPKINS, RONALD GARY · 2001 to 2010
$78.6M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
TLR4 signaling in the innate immune response to neonatal sepsisF32GM093665 · NIGMS · UNIVERSITY OF FLORIDA · PI CUENCA, ALEX · 2010 to 2010
$52k
NIGMS NIH HHS F32 GM093665NIGMS NIH HHS T32 GM008721NIGMS NIH HHS U54 GM062119
6 · The paper itself

Abstract

Despite ongoing improvements in resuscitation, care, and outcomes, traumatic injury remains a significant health care and economic burden. The causes are multifactorial, but our approach to the clinical management of these patients remains limited by our current understanding of the pathobiology of the disease. A multicenter, multidisciplinary program known as the "Inflammation and the Host Response to Injury" Large Scale Collaborative Research Program was created by the National Institute of General Medical Sciences (NIGMS, U54 GM062119-10) in 2001 in a 10-year effort to address some of these issues. Its primary goal is to describe the human genomic response to severe trauma and burns, and to examine changes in gene expression in the context of different clinical outcomes. The Program has not only successfully implemented clinical care guidelines for managing the severe trauma patient based on the best available evidence to minimize iatrogenic variability, but it has also examined the genome-wide, immune-inflammatory response in total and isolated blood leukocyte populations. This review will address current milestones as well as future directions for the Program.

Indexed as

Critical careInflammationPolytraumaProtocols

Identifiers

PMID26815465
PMCPMC6541206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.