ArticleEuropean radiology2016
Isoattenuating insulinomas at biphasic contrast-enhanced CT: frequency, clinicopathologic features and perfusion characteristics.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Quantitative Conspicuity of Pancreatic Canine Insulinoma: A Comparison of Dynamic 4D CT and Dual-Source, Dual-Energy Bolus-Triggered Multiphase CT Imaging.Veterinary sciences · 2025Article
- Insulinoma detection and surgery planning: a comparative study of 5.0T MRI versus 3.0T MRI and MDCT.Abdominal radiology (New York) · 2025Article
- Insulinoma detection on low-dose pancreatic CT perfusion: comparing with conventional contrast-enhanced CT and MRI.Insights into imaging · 2025Article
- Quantitative evaluation of pancreatic neuroendocrine tumors utilizing dual-source CT perfusion imaging.BMC medical imaging · 2024Article
- Hypovascular insulinoma with reduced microvessel density on histopathology: a case report.Diabetology international · 2024Article
- Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs.AJR. American journal of roentgenology · 2024Review
- Pancreatic CT perfusion: quantitative meta-analysis of disease discrimination, protocol development, and effect of CT parameters.Insights into imaging · 2023Article
- The comparison of three different molecular imaging methods in localization and grading of insulinoma.Frontiers in endocrinology · 2023Article
- Occult insulinoma with treatment refractory, severe hypoglycaemia in multiple endocrine neoplasia type 1 syndrome; difficulties faced during diagnosis, localization and management; a case report.BMC endocrine disorders · 2022Article
- Effect of HIV-1 Protease Inhibitor on IL-18 and IL-1Disease markers · 2022Article
- Multifocal autoimmune pancreatitis: A retrospective study in a single tertiary center of 26 patients with a 20-year literature review.World journal of gastroenterology · 2021Article
- Detection of insulinoma: one-stop pancreatic perfusion CT with calculated mean temporal images can replace the combination of bi-phasic plus perfusion scan.European radiology · 2020Article
- Homogenously isoattenuating insulinoma on biphasic contrast-enhanced computed tomography: Little benefits of diffusion-weighted imaging for lesion detection.Oncology letters · 2018Article
- CT during celiac artery angiography for localization of clinically suspected small insulinomas.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018Article
- Dynamic non-invasive ASL perfusion imaging of a normal pancreas with secretin augmented MR imaging.European radiology · 2018Article
- Sporadic insulinomas on volume perfusion CT: dynamic enhancement patterns and timing of optimal tumour-parenchyma contrast.European radiology · 2017Article
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7 authors.
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Abstract
objectivesWe aimed to determine the frequency of isoattenuating insulinomas, to investigate their clinicopathological features and to assess their regional pancreatic perfusion characteristics.
methodsInstitutional review board approval was obtained, and patient informed consent was waived. From July 2010 to June 2014, 170 patients (66 male, 104 female) with endogenous hyperinsulinemic hypoglycemia underwent biphasic contrast-enhanced CT before surgery, and 129 of those patients also received preoperative whole-pancreas CT perfusion. A total of 181 tumours were proved histopathologically after surgery. Enhancement pattern and regional pancreatic perfusion characteristics were analyzed. Clinical features, tumour size and pathological grading were investigated.
resultsThe frequency of isoattenuating tumours was 24.9 %. Tumour size and WHO grading was not significantly different between isoattenuating and hyperattenuating tumours. Tumour-free regions had identical blood flow (BF) regardless of their location (p = 0.35). Isoattenuating tumour-harbouring regions had lower BF compared with hyperattenuating tumour-harbouring regions; both showed higher BF compared with tumour-free neighbourhood regions (all p < 0.01). For patients with isoattenuating tumours, the overall hospital stay was longer (p < 0.01).
conclusionsA substantial subset of insulinomas were isoattenuating on biphasic CT. CT perfusion showed higher BF in tumour-harbouring regions compared to tumour-free regions, providing a clue for tumour regionalization. KEY POINTS: • About a quarter of all insulinomas were isoattenuating on biphasic contrast-enhanced CT. • CT perfusion finds tumour-harbouring regions have higher blood-flow compared to tumour-free regions. • CT perfusion provides important information for tumour regionalization, for isoattenuating tumours.
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