ArticleNature2016
The temporal scaling of Caenorhabditis elegans ageing.
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves.Scientific reports · 2018Pooled it
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- Slowed Gompertzian ageing in long-lived C. elegans results from expansion of decrepitude, not decelerated ageing.Nature communications · 2026Article
- The Strehler-Mildvan mortality correlation arises from changes in the variability of ageing.bioRxiv : the preprint server for biology · 2026Article
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- How and why does aging occur? Updating evolutionary theory to meet a new era of data.Evolution, medicine, and public health · 2026Article
- Distribution Analysis of the Lifespan Trait in Drosophila.International journal of molecular sciences · 2025Article
- Dying occurs as a defined molecular progression iniScience · 2025Article
- Scaling life as an interspecies hallmark of aging.Genes & development · 2025Review
- Beyond genes and environment: mapping biological stochasticity in aging.GeroScience · 2025Review
- Review
- Review
- Berberine Extends Lifespan inAntioxidants (Basel, Switzerland) · 2025Article
- Compression of morbidity by interventions that steepen the survival curve.Nature communications · 2025Article
- Similarities and differences in the gene expression signatures of physiological age versus future lifespan.Aging cell · 2025Article
- Demographics of co-ageing complex systems: from infected worms to chess games.Royal Society open science · 2024Article
- The Power of a Complex Systems Perspective to Elucidate Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Transcriptional drift in aging cells: A global decontroller.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The egg-counter: a novel microfluidic platform for characterization ofLab on a chip · 2024Article
- Single-worm quantitative proteomics reveals aging heterogeneity in isogenic Caenorhabditis elegans.Aging cell · 2024Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The process of ageing makes death increasingly likely, involving a random aspect that produces a wide distribution of lifespan even in homogeneous populations. The study of this stochastic behaviour may link molecular mechanisms to the ageing process that determines lifespan. Here, by collecting high-precision mortality statistics from large populations, we observe that interventions as diverse as changes in diet, temperature, exposure to oxidative stress, and disruption of genes including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pathway components daf-2, age-1, and daf-16 all alter lifespan distributions by an apparent stretching or shrinking of time. To produce such temporal scaling, each intervention must alter to the same extent throughout adult life all physiological determinants of the risk of death. Organismic ageing in Caenorhabditis elegans therefore appears to involve aspects of physiology that respond in concert to a diverse set of interventions. In this way, temporal scaling identifies a novel state variable, r(t), that governs the risk of death and whose average decay dynamics involves a single effective rate constant of ageing, kr. Interventions that produce temporal scaling influence lifespan exclusively by altering kr. Such interventions, when applied transiently even in early adulthood, temporarily alter kr with an attendant transient increase or decrease in the rate of change in r and a permanent effect on remaining lifespan. The existence of an organismal ageing dynamics that is invariant across genetic and environmental contexts provides the basis for a new, quantitative framework for evaluating the manner and extent to which specific molecular processes contribute to the aspect of ageing that determines lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.