Evidence map›Paper›PMID 26814588›Full record

ReviewNature neuroscience2016

Remodeling myelination: implications for mechanisms of neural plasticity.

Kae-Jiun Chang, Stephanie A Redmond, Jonah R Chan

Abstract readReview
In one paragraph

Review in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. The role of type I collagen in white matter injury.Anatomical science international · 2026
    Review
  7. Actin disassembly triggers CNS myelin compaction and wrapping.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Cortical myelin mapping in antipsychotic medication-naïve, first-episode psychosis patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Review
  18. Review
  19. OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kae-Jiun ChangDepartment of Neurology, University of California, San Francisco, California, USA.ORCID http://orcid.org/0000-0002-3656-7725
Stephanie A RedmondDepartment of Neurology, University of California, San Francisco, California, USA.ORCID http://orcid.org/0000-0002-5580-6269
Jonah R ChanDepartment of Neurology, University of California, San Francisco, California, USA.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
TRANSGENIC MOUSE MODELS TO STUDY OVARIAN FUNCTIONU54HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI RICHARDS, JOANNE STEWART · 1998 to 2013
$19.9M
THE ESTABLISHMENT OF SCHWANN CELL POLARITY AND THE INITIATION OF MYELINATIONR01NS062796 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAN, JONAH R · 2008 to 2018
$3.4M
Functional Screening of GPCR Small Molecule Libraries for Remyelination TherapiesR01NS095889 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JONAH R · 2016 to 2020
$1.9M
GROWTH AND DIFFERENTIATION IN EUKARYOTEST32HD007495 · NICHD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KINTNER, CHRISTOPHER ROBERT · 1995 to 2009
$1.6M
Determining the Role of Dendrite Inhibition in Oligodendrocyte MyelinationF31NS081905 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REDMOND, STEPHANIE · 2013 to 2015
$82k
TRANSGENIC ANIMAL--COREP30HD007495 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GLASSER, STANLEY R · 1985 to 1997
–
NCI NIH HHS CA125123NCI NIH HHS P30 CA125123NICHD NIH HHS HD007495NICHD NIH HHS P30 HD007495NICHD NIH HHS T32 HD007495NICHD NIH HHS U54 HD007495NIDDK NIH HHS DK56338NIDDK NIH HHS P30 DK056338NINDS NIH HHS F31 NS081905NINDS NIH HHS F31NS081905NINDS NIH HHS R01 NS062796NINDS NIH HHS R01NS062796NINDS NIH HHS R01 NS095889
6 · The paper itself

Abstract

One of the most significant paradigm shifts in membrane remodeling is the emerging view that membrane transformation is not exclusively controlled by cytoskeletal rearrangement, but also by biophysical constraints, adhesive forces, membrane curvature and compaction. One of the most exquisite examples of membrane remodeling is myelination. The advent of myelin was instrumental in advancing the nervous system during vertebrate evolution. With more rapid and efficient communication between neurons, faster and more complex computations could be performed in a given time and space. Our knowledge of how myelin-forming oligodendrocytes select and wrap axons has been limited by insufficient spatial and temporal resolution. By virtue of recent technological advances, progress has clarified longstanding controversies in the field. Here we review insights into myelination, from target selection to axon wrapping and membrane compaction, and discuss how understanding these processes has unexpectedly opened new avenues of insight into myelination-centered mechanisms of neural plasticity.

Indexed as

AnimalsAxonsCell MembraneHumansMyelin SheathNeuronal PlasticityNeurons

Identifiers

PMID26814588
PMCPMC4792270

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.