ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2012
Predictive ability of the ISS, NISS, and APACHE II score for SIRS and sepsis in polytrauma patients.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Early Sex Differences in pH, Base Excess and Lactate for the Prediction of Mortality in Trauma Patients.Bioengineering (Basel, Switzerland) · 2026Article
- Patterns of sex-specific outcomes and mortality in polytrauma: a demographic and epidemiologic analysis by injury severity score.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Observational
- Prothrombin time predicting time-dependent and risk-stratified mortality in polytrauma patients.International journal of emergency medicine · 2025Article
- Epidemiology, Risk Factors, and Predictive Modelling of Post-Traumatic Sepsis: A Retrospective Cohort Study.Risk management and healthcare policy · 2025Article
- Polytrauma scoring revisited: prognostic validity and usability in daily clinical practice.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Developing an early warning system for detecting sepsis in patients with trauma.International wound journal · 2024Article
- Neutrophil-to-lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis.Immunity, inflammation and disease · 2023Article
- The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway ExplorerJournal of surgery and research · 2022Article
- Validation of a Visual-Based Analytics Tool for Outcome Prediction in Polytrauma Patients (WATSON Trauma Pathway Explorer) and Comparison with the Predictive Values of TRISS.Journal of clinical medicine · 2021Article
- Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation.Biomolecules · 2021Review
- SOFA score is superior to APACHE-II score in predicting the prognosis of critically ill patients with acute kidney injury undergoing continuous renal replacement therapy.Renal failure · 2020Article
- How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales.PloS one · 2020Article
- Evaluation of Protein Carbonyl Content in Healthy and Sick Hospitalized Horses.Frontiers in veterinary science · 2020Article
- Development and validation of a novel predictive score for sepsis risk among trauma patients.World journal of emergency surgery : WJES · 2019Article
- Characterizing the relationship between systemic inflammatory response syndrome and early cardiac dysfunction in traumatic brain injury.Journal of neuroscience research · 2018Article
- Resuscitation with polymeric plasma substitutes is permissive for systemic inflammatory response syndrome and sepsis in multiply injured patients: a retrospective cohort study.European journal of medical research · 2016Article
- Can APACHE II, SOFA, ISS, and RTS Severity Scores be used to Predict Septic Complications in Multiple Trauma Patients?Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
- Have Severity Scores a Place in Predicting Septic Complications in ICU Multiple Trauma Patients?Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
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Authors and funding
4 authors.
Funding
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Abstract
purposeSystemic inflammatory response syndrome (SIRS) and sepsis as causes of multiple organ dysfunction syndrome (MODS) remain challenging to treat in polytrauma patients. In this study, the focus was set on widely used scoring systems to assess their diagnostic quality.
methodsA total of 512 patients (mean age: 39.2 ± 16.2, range: 16-88 years) who had an Injury Severity Score (ISS) ≥17 were included in this retrospective study. The patients were subdivided into four groups: no SIRS, slight SIRS, severe SIRS, and sepsis. The ISS, New Injury Severity Score (NISS), Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and prothrombin time were collected at admission. The Kruskal-Wallis test and χ(2)-test, multinomial regression analysis, and kernel density estimates were performed. Receiver operating characteristic (ROC) analysis is reported as the area under the curve (AUC). Data were considered as significant if p < 0.05.
resultsAll variables were significantly different in all groups (p < 0.001). The odds ratio increased with increasing SIRS severity for NISS (slight vs. no SIRS, 1.06, p = 0.07; severe vs. no SIRS, 1.07, p = 0.04; and sepsis vs. no SIRS, 1.11, p = 0.0028) and APACHE II score (slight vs. no SIRS, 0.97, p = 0.44; severe vs. no SIRS, 1.08, p = 0.02; and sepsis vs. no SIRS, 1.12, p = 0.0028). ROC analysis revealed that the NISS (slight vs. no SIRS, AUC 0.61; severe vs. no SIRS, AUC 0.67; and sepsis vs. no SIRS, AUC 0.77) and APACHE II score (slight vs. no SIRS, AUC 0.60; severe vs. no SIRS, AUC 0.74; and sepsis vs. no SIRS, AUC 0.82) had the best predictive ability for SIRS and sepsis.
conclusionQuick assessment with the NISS or APACHE II score could preselect possible candidates for sepsis following polytrauma and provide guidance in trauma surgeons' decision-making.
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