Evidence map›Paper›PMID 26814442›Full record

ArticleCancer2016

Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation.

Heather S L Jim, Steven K Sutton, Paul B Jacobsen, Paul J Martin, Mary E Flowers, Stephanie J Lee

Registry-linked trialOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06118853 (Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein), which is not on this map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06118853 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2023 to 2025Enrolled35ConditionsHematopoietic Stem Cell Transplantation, Bone Marrow TransplantationArmsyoga or gentle massage plus standard treatment for HSCT
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Who Enrolls in an Online Cancer Survivorship Program? Reach of the INSPIRE Randomized Controlled Trial for Hematopoietic Cell Transplantation Survivors.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Trial
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Modern-Era Challenges in the Clinical Management of Graft-Versus-Host Disease.Advances in experimental medicine and biology · 2025
    Review
  12. Article
  13. Trajectories and risk factors of fatigue following colorectal cancer diagnosis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2023
    Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Heather S L JimHealth Outcomes and Behavior Department, Moffitt Cancer Center, Tampa, Florida.
Steven K SuttonBiostatistics Department, Moffitt Cancer Center, Tampa, Florida.
Paul B JacobsenHealth Outcomes and Behavior Department, Moffitt Cancer Center, Tampa, Florida.
Paul J MartinClinical Research Division, Fred Hutchison Cancer Research Center, Seattle, Washington.
Mary E FlowersClinical Research Division, Fred Hutchison Cancer Research Center, Seattle, Washington.
Stephanie J LeeClinical Research Division, Fred Hutchison Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · USMoffitt Cancer Center · US

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
Mind-Body Interactions in Neuro-Oncology Family CaregiversR01CA118711 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHERWOOD, PAULA R · 2007 to 2011
$2.0M
Genetic Predictors of Cognitive Function, Depression and Fatigue in CancerK07CA138499 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JIM, HEATHER S.L. · 2009 to 2013
$713k
NCI NIH HHS K07 CA138499NCI NIH HHS NIH K07-CA138499NCI NIH HHS NIH P01-CA018029NCI NIH HHS P01 CA018029NCI NIH HHS R01 CA118711
6 · The paper itself

Abstract

backgroundPatients treated with hematopoietic cell transplantation (HCT) often experience depression and fatigue but analyses to determine risk factors have typically lacked statistical power. The current study examined sociodemographic and clinical risk factors for depression and fatigue in a large cohort of survivors of HCT.

methodsMeasures of depression and fatigue were included in an annual survey of HCT recipients that also included self-reported sociodemographic and health information. Patient clinical characteristics were obtained from the clinical database.

resultsThe sample consisted of 1869 recipients (with a mean age of 56 years; 53% male) who were a mean of 13 years (allogeneic recipients) and 6 years (autologous recipients) from HCT. Moderate to severe depression was reported by 13% of participants; moderate to severe fatigue was reported by 42%. Among allogeneic recipients, female sex, younger age, current presence of chronic pain, and current patient-reported severity of chronic graft-versus-host disease were found to be independently associated with greater depression whereas female sex, current presence of chronic pain, and current severity of chronic graft-versus-host disease were independently associated with greater fatigue (P values <.01). Among autologous recipients, younger age and current presence of chronic pain were found to be independently associated with both greater depression and greater fatigue (P values <.01).

conclusionsRates of depression and fatigue in this group of survivors suggest a high symptom burden. Better screening, referral, and interventions are needed.

Indexed as

Surveys and QuestionnairesAdultAgedAged, 80 and overAge FactorsAnalysis of VarianceCross-Sectional StudiesDepressionFatigueFemaleGraft RejectionGraft SurvivalHematopoietic Stem Cell TransplantationHumansLogistic ModelsMaledepressionfatiguehematopoietic cell transplantationneoplasmsquality of life

Identifiers

PMID26814442
PMCPMC7091560
OpenAlexW2257342655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.