ArticleNature communications2016
Global metagenomic survey reveals a new bacterial candidate phylum in geothermal springs.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Branched-chain amino acid specialization drove diversification within Calditenuaceae (Caldarchaeia) and enables their cultivation.Nature communications · 2026Article
- Global metagenomics reveals plastid diversity and unexplored algal lineages.Nature communications · 2026Article
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- Metagenomic expansion of Joyebacterota identifiesISME communications · 2026Article
- Metabolic interdependencies in thermophilic communities are revealed using co-occurrence and complementarity networks.Nature communications · 2024Article
- Mining microbial and metabolic dark matter in extreme environments: a roadmap for harnessing the power of multi-omics data.Advanced biotechnology · 2024Review
- Evaluation of the safety and efficacy of fecal microbiota transplantations in bottlenose dolphins (Tursiops truncatus) using metagenomic sequencing.Journal of applied microbiology · 2024Article
- Adaptation strategies of giant viruses to low-temperature marine ecosystems.The ISME journal · 2024Article
- Deep-branching evolutionary intermediates reveal structural origins of form I rubisco.Current biology : CB · 2023Article
- Resource partitioning and amino acid assimilation in a terrestrial geothermal spring.The ISME journal · 2023Article
- Synthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium.Microbiome · 2023Article
- Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats.Nature microbiology · 2023Article
- Hyperactive nanobacteria with host-dependent traits pervade Omnitrophota.Nature microbiology · 2023Article
- Comparison of long- and short-read metagenomic assembly for low-abundance species and resistance genes.Briefings in bioinformatics · 2023Article
- Genomic insight and physiological characterization of thermoacidophilicFrontiers in microbiology · 2023Article
- Comparison of Metagenomics and Metatranscriptomics Tools: A Guide to Making the Right Choice.Genes · 2022Article
- Enhanced terrestrial Fe(II) mobilization identified through a novel mechanism of microbially driven cave formation in Fe(III)-rich rocks.Scientific reports · 2022Article
- Many dissimilar NusG protein domains switch between α-helix and β-sheet folds.Nature communications · 2022Article
- Phylogenomic Analyses and Molecular Signatures Elucidating the Evolutionary Relationships amongst theMicroorganisms · 2022Article
- Evolving Perspective on the Origin and Diversification of Cellular Life and the Virosphere.Genome biology and evolution · 2022Review
15 more citing papers are in PubMed but not listed here.
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19 authors.
Funding
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Abstract
Analysis of the increasing wealth of metagenomic data collected from diverse environments can lead to the discovery of novel branches on the tree of life. Here we analyse 5.2 Tb of metagenomic data collected globally to discover a novel bacterial phylum ('Candidatus Kryptonia') found exclusively in high-temperature pH-neutral geothermal springs. This lineage had remained hidden as a taxonomic 'blind spot' because of mismatches in the primers commonly used for ribosomal gene surveys. Genome reconstruction from metagenomic data combined with single-cell genomics results in several high-quality genomes representing four genera from the new phylum. Metabolic reconstruction indicates a heterotrophic lifestyle with conspicuous nutritional deficiencies, suggesting the need for metabolic complementarity with other microbes. Co-occurrence patterns identifies a number of putative partners, including an uncultured Armatimonadetes lineage. The discovery of Kryptonia within previously studied geothermal springs underscores the importance of globally sampled metagenomic data in detection of microbial novelty, and highlights the extraordinary diversity of microbial life still awaiting discovery.
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