Trial reportEuropean journal of clinical nutrition2016
Maternal obesity during pregnancy is negatively associated with maternal and neonatal iron status.
Trial report in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Investigation of the association between maternal serum ferritin levels and preterm delivery: A systematic review and meta-analyses.Archives of gynecology and obstetrics · 2026Pooled it
- Association between overweight/obesity and iron deficiency anaemia among women of reproductive age: a systematic review.Public health nutrition · 2024Pooled it
- The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.Scientific reports · 2021Pooled it
- Maternal Adiposity and DNA Methylation of TfR2 and HJV Genes in Early Pregnancy: Mediating Role of Inflammation and Consequences for Iron Status.The Journal of nutrition · 2026Trial
- Maternal iron kinetics and maternal-fetal iron transfer in normal-weight and overweight pregnancy.The American journal of clinical nutrition · 2022Trial
- Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.The Journal of nutrition · 2021Trial
- Screening umbilical cord blood for congenital Iron deficiency.Blood cells, molecules & diseases · 2019Trial
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Article
- Effects of prenatal iron deficiency on neurological development and related disorders in offspring.Frontiers in nutrition · 2025Review
- Article
- A multilevel analysis of the triple burden of malnutrition in Indonesia: trends and determinants from repeated cross-sectional surveys.BMC public health · 2023Article
- Preliminary Study of Iron Concentration in the Human Placenta in Twin Pregnancies.Biomolecules · 2023Article
- Trends in the Intraindividual Double Burden of Overweight/Obesity and Anemia among Adult Women Living in 33 Low- and Middle-Income Countries: A Secondary Analysis of Demographic and Health Surveys from 2000-2019.The Journal of nutrition · 2023Article
- Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity.Nature reviews. Endocrinology · 2022Review
- Impact and interactions between risk factors on the iron status of at-risk neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Intra-household double burden of overweight/obesity and anaemia: Evidence from 49 low-and middle-income countries.Maternal & child nutrition · 2022Article
- Review
- Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity.Journal of nutritional science · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesObesity among pregnant women may adversely affect both maternal iron status throughout pregnancy and placental transfer of iron. The objective of this study was to determine the association of maternal body mass index (BMI) with (1) maternal iron status and inflammation in mid and late pregnancy, (2) the change in maternal iron status throughout pregnancy and (3) neonatal iron status. SUBJECTS/
methodsWe examined longitudinal data from 1613 participants in a pregnancy iron supplementation trial in rural China. Women with uncomplicated singleton pregnancies were enrolled in the early second trimester of pregnancy and followed through parturition. Maternal blood samples obtained at enrollment and in the third trimester and cord blood samples were analyzed for a range of hematological and iron biomarkers.
resultsThere was a negative association between maternal BMI and iron status at enrollment (transferrin receptor (sTfR): r=0.20, P<0.001; body iron (BI): r=-0.05; P=0.03). This association was markedly stronger among obese women. Maternal BMI was positively associated with maternal inflammation (C-reactive protein: r=0.33, P<0.001). In multiple linear regression models, maternal BMI was negatively associated with neonatal iron status (cord serum ferritin: -0.01, P=0.008; BI: -0.06, P=0.006) and associated with a lower decrease in iron status throughout pregnancy (sTfR: -4.6, P<0.001; BI: 1.1, P=0.004).
conclusionsMaternal obesity during pregnancy may adversely affect both maternal and neonatal iron status, potentially through inflammatory pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.