ReviewNature reviews. Clinical oncology2016
Squamous-cell carcinoma of the anus: progress in radiotherapy treatment.
Review in Nature reviews. Clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Organ-sparing radiotherapy in penile cancer: therapeutic approaches.International urology and nephrology · 2026Pooled it
- Estimated dose to site of loco-regional recurrence after radiotherapy in anal cancer using point of origin methods.Physics and imaging in radiation oncology · 2023Article
- Quality of life in patients treated with radiochemotherapy for primary diagnosis of anal cancer.Scientific reports · 2022Article
- Article
- Evolution of the Role of Radiotherapy for Anal Cancer.Cancers · 2021Review
- Treatment outcome after radiochemotherapy in anal cancer patients staged withClinical and translational radiation oncology · 2020Article
- Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.Current oncology (Toronto, Ont.) · 2020Article
- Pooled Analysis of external-beam RADiotherapy parameters in phase II and phase III trials in radiochemotherapy in Anal Cancer (PARADAC).European journal of cancer (Oxford, England : 1990) · 2019Review
- Comparing simultaneous integrated boost vs sequential boost in anal cancer patients: results of a retrospective observational study.Radiation oncology (London, England) · 2018Observational
- The impact of contour variation on tumour control probability in anal cancer.Radiation oncology (London, England) · 2018Article
- Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography.Radiation oncology (London, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemoradiotherapy is the standard-of-care treatment of squamous-cell carcinoma of the anus (SCCA), and this has not changed in decades. Radiation doses of 50-60 Gy, as used in many phase III trials, result in substantial late morbidities and fail to control larger and node-positive tumours. Technological advances in radiation therapy are improving patient outcomes and quality of life, and should be applied to patients with SCCA. Modern techniques such as intensity-modulated radiotherapy (IMRT), rotational IMRT, image-guided radiotherapy using cone-beam CT, and stereotactic techniques have enabled smaller margins and highly conformal plans, resulting in decreased radiation doses to the organs at risk and ensuring a shorter overall treatment time. In this Perspectives article, the use of novel approaches to target delineation, optimized radiotherapy techniques, adaptive radiotherapy, dose-escalation with external-beam radiotherapy (EBRT) or brachytherapy, and the potential for modified fractionation are discussed in the context of SCCA.
Indexed as
Identifiers
26813935What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.