ArticleJournal of the American Heart Association2016
Consumption of Caffeinated Products and Cardiac Ectopy.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Coffee and Real-time Atrial and Ventricular Ectopy
Risk Stratifications for Patients Come With Palpitations in Assiut and Suez Canal University Hospitals
Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Acute Effects of Coffee Consumption on Health among Ambulatory Adults.The New England journal of medicine · 2023Trial
- Extreme hypercalcemia secondary to parathyroid adenoma obscured by excessive coffee consumption and premature ventricular complexes.Journal of general and family medicine · 2025Article
- The Role of Xenobiotic Caffeine on Cardiovascular Health: Promises and Challenges.Journal of xenobiotics · 2025Review
- The risk of premature cardiac contractions (PAC/PVC) related to caffeine consumption among healthcare workers: A comprehensive review.Health science reports · 2024Article
- Effects of moderate caffeine intake in athletes.European journal of internal medicine · 2024Article
- Caffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility.Journal of the Saudi Heart Association · 2024Review
- Alcohol and caffeine synergistically induce spontaneous ventricular tachyarrhythmias: ameliorated with dantrolene treatment.Heart rhythm O2 · 2023Article
- Effect of Caffeine Consumption on Cardiovascular Disease: An Updated Review.Pharmaceutical medicine · 2023Review
- Atrial fibrillation: primary prevention, secondary prevention, and prevention of thromboembolic complications: part 1.Frontiers in cardiovascular medicine · 2023Review
- Coffee and cardiac arrhythmias: Up-date review of the literature and clinical studies.Cardiology journal · 2023Review
- Causal relationship between tea intake and cardiovascular diseases: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Coffee Consumption and Incident Tachyarrhythmias: Reported Behavior, Mendelian Randomization, and Their Interactions.JAMA internal medicine · 2021Article
- The Ubiquitous Premature Ventricular Complex.Cureus · 2020Review
- Approach to Management of Premature Ventricular Contractions.Current treatment options in cardiovascular medicine · 2019Review
- Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.Journal of atrial fibrillation · 2019Article
- Caffeine Consumption and Cardiovascular Risks: Little Cause for Concern.Journal of the American Heart Association · 2016Article
- Energy Drinks: A Clinical Primer and National Data Update.Missouri medicineArticle
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPremature cardiac contractions are associated with increased morbidity and mortality. Though experts associate premature atrial contractions (PACs) and premature ventricular contractions (PVCs) with caffeine, there are no data to support this relationship in the general population. As certain caffeinated products may have cardiovascular benefits, recommendations against them may be detrimental. METHODS AND
resultsWe studied Cardiovascular Health Study participants with a baseline food frequency assessment, 24-hour ambulatory electrocardiography (Holter) monitoring, and without persistent atrial fibrillation. Frequencies of habitual coffee, tea, and chocolate consumption were assessed using a picture-sort food frequency survey. The main outcomes were PACs/h and PVCs/hour. Among 1388 participants (46% male, mean age 72 years), 840 (61%) consumed ≥1 caffeinated product per day. The median numbers of PACs and PVCs/h and interquartile ranges were 3 (1-12) and 1 (0-7), respectively. There were no differences in the number of PACs or PVCs/h across levels of coffee, tea, and chocolate consumption. After adjustment for potential confounders, more frequent consumption of these products was not associated with ectopy. In examining combined dietary intake of coffee, tea, and chocolate as a continuous measure, no relationships were observed after multivariable adjustment: 0.48% fewer PACs/h (95% CI -4.60 to 3.64) and 2.87% fewer PVCs/h (95% CI -8.18 to 2.43) per 1-serving/week increase in consumption.
conclusionsIn the largest study to evaluate dietary patterns and quantify cardiac ectopy using 24-hour Holter monitoring, we found no relationship between chronic consumption of caffeinated products and ectopy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.