ArticleScientific reports2016
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
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- Women's neuroplasticity during gestation, childbirth and postpartum.Nature neuroscience · 2024Article
- Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-κB/MAPK Pathway.Molecular neurobiology · 2024Article
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- Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease.Scientific reports · 2022Article
- Coil Combination of Multichannel Single Voxel Magnetic Resonance Spectroscopy with Repeatedly Sampled In Vivo Data.Molecules (Basel, Switzerland) · 2021Article
- Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease.Brain, behavior, and immunity · 2020Article
- Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation.Frontiers in immunology · 2020Article
- Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019Article
- In vivo molecular imaging of neuroinflammation in Alzheimer's disease.Journal of neurochemistry · 2019Review
- Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings.PloS one · 2019Article
- Miniature pig magnetic resonance spectroscopy model of normal adolescent brain development.Journal of neuroscience methods · 2018Article
- Microglial priming in Alzheimer's disease.Annals of translational medicine · 2018Review
- Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons.Scientific reports · 2018Article
- Longitudinal investigation of neuroinflammation and metabolite profiles in the APPJournal of neurochemistry · 2018Article
- Putative Astroglial Dysfunction in Schizophrenia: A Meta-Analysis ofFrontiers in psychiatry · 2018Article
- Clinical PET Imaging of Microglial Activation: Implications for Microglial Therapeutics in Alzheimer's Disease.Frontiers in aging neuroscience · 2018Review
- Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Microglia activation has emerged as a potential key factor in the pathogenesis of Alzheimer's disease. Metabolite levels assessed by magnetic resonance spectroscopy (MRS) are used as markers of neuroinflammation in neurodegenerative diseases, but how they relate to microglial activation in health and chronic disease is incompletely understood. Using MRS, we monitored the brain metabolic response to lipopolysaccharides (LPS)-induced microglia activation in vivo in a transgenic mouse model of Alzheimer's disease (APP/PS1) and healthy controls (wild-type (WT) littermates) over 4 hours. We assessed reactive gliosis by immunohistochemistry and correlated metabolic and histological measures. In WT mice, LPS induced a microglial phenotype consistent with activation, associated with a sustained increase in macromolecule and lipid levels (ML9). This effect was not seen in APP/PS1 mice, where LPS did not lead to a microglial response measured by histology, but induced a late increase in the putative inflammation marker myoinositol (mI) and metabolic changes in total creatine and taurine previously reported to be associated with amyloid load. We argue that ML9 and mI distinguish the response of WT and APP/PS1 mice to immune mediators. Lipid and macromolecule levels may represent a biomarker of activation of healthy microglia, while mI may not be a glial marker.
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Registered trials
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