ArticleEuropean radiology2016
Performance of ultralow-dose CT with iterative reconstruction in lung cancer screening: limiting radiation exposure to the equivalent of conventional chest X-ray imaging.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Feasibility of AI-Denoised Ultra-Low-Dose CT for Detection of Acute Pelvic and Hip Fractures: A Pilot Multi-Reader Study.Diagnostics (Basel, Switzerland) · 2026Article
- Improving visibility of small anatomical details on low and ultra-low dose computed tomography with artificial intelligence-based image reconstructions.Radiation protection dosimetry · 2026Article
- Impact of Simulated Reduced-Dose Chest CT on Diagnosing Pulmonary T1 Tumors and Patient Management.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Radiation Exposure to Low-Dose Computed Tomography for Lung Cancer Screening: Should We Be Concerned?Tomography (Ann Arbor, Mich.) · 2023Review
- Diagnostic validation of a deep learning nodule detection algorithm in low-dose chest CT: determination of optimized dose thresholds in a virtual screening scenario.European radiology · 2022Article
- Low-dose CT for lung cancer screening: position paper from the Italian college of thoracic radiology.La Radiologia medica · 2022Article
- The Journey for Lung Cancer Screening where we Stand Today.The open respiratory medicine journal · 2022Review
- Establishing scanning protocols for a CT lung cancer screening trial in the UK.The British journal of radiology · 2021Article
- Image quality of ultralow-dose chest CT using deep learning techniques: potential superiority of vendor-agnostic post-processing over vendor-specific techniques.European radiology · 2021Article
- Comparison of clinical diagnostic value of spiral CT with different dose in patients with early-stage peripheral lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Dosimetry and Comparison between Different CT Protocols (Low Dose, Ultralow Dose, and Conventional CT) for Lung Nodules' Detection in a Phantom.Radiology research and practice · 2021Article
- Observer Performance for Detection of Pulmonary Nodules at Chest CT over a Large Range of Radiation Dose Levels.Radiology · 2020Article
- Feasibility of bronchial wall quantification in low- and ultralow-dose third-generation dual-source CT: An ex vivo lung study.Journal of applied clinical medical physics · 2020Article
- ESR/ERS statement paper on lung cancer screening.European radiology · 2020Review
- Detection and Independent Validation of Model-Based Quantitative Transcriptional Regulation Relationships Altered in Lung Cancers.Frontiers in bioengineering and biotechnology · 2020Article
- Article
- Detection of pulmonary nodules: a clinical study protocol to compare ultra-low dose chest CT and standard low-dose CT using ASIR-V.BMJ open · 2019Article
- Magnetic Resonance Spectroscopy-based Metabolomic Biomarkers for Typing, Staging, and Survival Estimation of Early-Stage Human Lung Cancer.Scientific reports · 2019Article
- Added Value of Ultra-low-dose Computed Tomography, Dose Equivalent to Chest X-Ray Radiography, for Diagnosing Chest Pathology.Journal of thoracic imaging · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the detection rate of pulmonary nodules in ultralow-dose CT acquisitions. MATERIALS AND
methodsIn this lung phantom study, 232 nodules (115 solid, 117 ground-glass) of different sizes were randomly distributed in a lung phantom in 60 different arrangements. Every arrangement was acquired once with standard radiation dose (100 kVp, 100 references mAs) and once with ultralow radiation dose (80 kVp, 6 mAs). Iterative reconstruction was used with optimized kernels: I30 for ultralow-dose, I70 for standard dose and I50 for CAD. Six radiologists examined the axial 1-mm stack for solid and ground-glass nodules. During a second and third step, three radiologists used maximum intensity projection (MIPs), finally checking with computer-assisted detection (CAD), while the others first used CAD, finally checking with the MIPs.
resultsThe detection rate was 95.5 % with standard dose (DLP 126 mGy*cm) and 93.3 % with ultralow-dose (DLP: 9 mGy*cm). The additional use of either MIP reconstructions or CAD software could compensate for this difference. A combination of both MIP reconstructions and CAD software resulted in a maximum detection rate of 97.5 % with ultralow-dose.
conclusionLung cancer screening with ultralow-dose CT using the same radiation dose as a conventional chest X-ray is feasible. KEY POINTS: • 93.3 % of all lung nodules were detected with ultralow-dose CT. • A sensitivity of 97.5 % is possible with additional image post-processing. • The radiation dose is comparable to a standard radiography in two planes. • Lung cancer screening with ultralow-dose CT is feasible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.