ArticleBone & joint research2016
Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis.
Article in Bone & joint research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Design and validation of a biomechanics device for preclinical arthrofibrosis models.Bone & joint research · 2026Article
- Prospective clinical trial analyzing serum mast cell tryptase levels and arthrofibrosis rates after total knee arthroplasty.Bone & joint research · 2025Article
- Early Anti-Inflammatory Effect of Bupivacaine-Meloxicam Therapy in a Rabbit Model of Arthrofibrosis.Tissue engineering. Part C, Methods · 2025Article
- An Abbreviated Rabbit Knee Model of Joint Contracture.Tissue engineering. Part C, Methods · 2025Article
- Capsule release surgery temporarily reduces contracture in a rat elbow model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Efficacy of ADIPOR1 and ADIPOR2 peptide-agonist AdipoRon in preventing contracture in a rabbit model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Nonsteroidal Anti-Inflammatory Drugs and Oral Corticosteroids Mitigated the Risk of Arthrofibrosis After Total Knee Arthroplasty.The Journal of arthroplasty · 2023Article
- The Safety of Adiponectin Receptor Agonist AdipoRon in a Rabbit Model of Arthrofibrosis.Tissue engineering. Part C, Methods · 2023Article
- Knee immobilization reproduces key arthrofibrotic phenotypes in mice.Bone & joint research · 2023Article
- Immune cell populations differ in patients undergoing revision total knee arthroplasty for arthrofibrosis.Scientific reports · 2022Article
- Biomechanical, histological, and molecular characterization of a new posttraumatic model of arthrofibrosis in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Intra-articular celecoxib improves knee extension regardless of surgical release in a rabbit model of arthrofibrosis.Bone & joint research · 2022Article
- Acquired Idiopathic Stiffness After Contemporary Total Knee Arthroplasty: Incidence, Risk Factors, and Results Over 25 Years.The Journal of arthroplasty · 2021Article
- Absence of signature inflammatory markers in synovial fluid for total knee arthroplasties revised for arthrofibrosis.Orthopaedics & traumatology, surgery & research : OTSR · 2021Article
- A Potential Theragnostic Regulatory Axis for Arthrofibrosis Involving Adiponectin (ADIPOQ) Receptor 1 and 2 (ADIPOR1 and ADIPOR2), TGFβ1, and Smooth Muscle α-Actin (ACTA2).Journal of clinical medicine · 2020Article
- Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Anti-fibrotic effects of the antihistamine ketotifen in a rabbit model of arthrofibrosis.Bone & joint research · 2020Article
- Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model.Drug design, development and therapy · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAnimal models have been developed that allow simulation of post-traumatic joint contracture. One such model involves contracture-forming surgery followed by surgical capsular release. This model allows testing of antifibrotic agents, such as rosiglitazone.
methodsA total of 20 rabbits underwent contracture-forming surgery. Eight weeks later, the animals underwent a surgical capsular release. Ten animals received rosiglitazone (intramuscular initially, then orally). The animals were sacrificed following 16 weeks of free cage mobilisation. The joints were tested biomechanically, and the posterior capsule was assessed histologically and via genetic microarray analysis.
resultsThere was no significant difference in post-traumatic contracture between the rosiglitazone and control groups (33° (standard deviation (sd) 11) vs 37° (sd14), respectively; p = 0.4). There was no difference in number or percentage of myofibroblasts. Importantly, there were ten genes and 17 pathways that were significantly modulated by rosiglitazone in the posterior capsule. DISCUSSION: Rosiglitazone significantly altered the genetic expression of the posterior capsular tissue in a rabbit model, with ten genes and 17 pathways demonstrating significant modulation. However, there was no significant effect on biomechanical or histological properties.Cite this article: M. P. Abdel. Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis. Bone Joint Res 2016;5:11-17. doi: 10.1302/2046-3758.51.2000593.
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