Evidence map›Paper›PMID 26813304›Full record

ReviewCurrent pharmaceutical biotechnology

Controlled Drug Delivery Using Microdevices.

Sharma T Sanjay, Maowei Dou, Guanglei Fu, Feng Xu, XiuJun Li

Abstract readReview
In one paragraph

Review in Current pharmaceutical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharma T Sanjay
Maowei Dou
Guanglei Fu
Feng Xu
XiuJun LiDepartment of Chemistry, Faculty of University of Texas at El Paso, 500 West University Ave, El Paso, Texas 79968, USA. xli4@utep.edu.

Funding

Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis DiagnosSC2GM105584 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI LI, XIUJUN · 2013 to 2015
$438k
Design of Point of Care Device for the Rapid Diagnosis of PertussisR21AI107415 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI DOMINGUEZ, DELFINA C, LI, XIUJUN · 2015 to 2016
$405k
NIAID NIH HHS R21 AI107415NIGMS NIH HHS SC2 GM105584
6 · The paper itself

Abstract

Therapeutic drugs administered systematically are evenly distributed to the whole body through blood circulation and have to cross many biological barriers before reaching the pathological site. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the urinary system resulting in suboptimal concentration of drugs at the desired site. Controlled drug delivery aims to localize the pharmacological activity of the drug to the desired site at desired release rates. The advances made by micro/nanofluidic technologies have provided new opportunities for better-controlled drug delivery. Various components of a drug delivery system can be integrated within a single tiny micro/nanofluidic chip. This article reviews recent advances of controlled drug delivery made by microfluidic/nanofluidic technologies. We first discuss microreservoir-based drug delivery systems. Then we highlight different kinds of microneedles used for controlled drug delivery, followed with a brief discussion about the current limitations and the future prospects of controlled drug delivery systems.

Indexed as

Drug Delivery SystemsLab-On-A-Chip DevicesAnimalsHumansNeedles

Identifiers

PMID26813304
PMCPMC5135015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.