Evidence map›Paper›PMID 26813289›Full record

ArticleRegenerative biomaterials2015

Next-generation resorbable polymer scaffolds with surface-precipitated calcium phosphate coatings.

Jinku Kim, Maria Hanshella R Magno, Ophir Ortiz, Sean McBride, Aniq Darr, Joachim Kohn, Jeffrey O Hollinger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jinku KimBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Maria Hanshella R MagnoBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Ophir OrtizBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Sean McBrideBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Aniq DarrBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Joachim KohnBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Jeffrey O HollingerBone Tissue Engineering Center, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15219, USA, Department of Bio and Chemical Engineering, Hongik University, Sejong, Korea 339-701 and Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Rutgers, The State University of New Jersey · US

Funding

RESBIO - the Technology Resource for Polymeric BiomaterialsP41EB001046 · NIBIB · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI KOHN, JOACHIM B. · 2003 to 2017
$17.0M
Translational Research in Regenerative MedicineT32EB005583 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM, PAREKKADAN, BIJU · 2006 to 2022
$4.7M
NIBIB NIH HHS P41 EB001046NIBIB NIH HHS T32 EB005583
6 · The paper itself

Abstract

Next-generation synthetic bone graft therapies will most likely be composed of resorbable polymers in combination with bioactive components. In this article, we continue our exploration of E1001(1k), a tyrosine-derived polycarbonate, as an orthopedic implant material. Specifically, we use E1001(1k), which is degradable, nontoxic, and osteoconductive, to fabricate porous bone regeneration scaffolds that were enhanced by two different types of calcium phosphate (CP) coatings: in one case, pure dicalcium phosphate dihydrate was precipitated on the scaffold surface and throughout its porous structure (E1001(1k) + CP). In the other case, bone matrix minerals (BMM) such as zinc, manganese and fluoride were co-precipitated within the dicalcium phosphate dihydrate coating (E1001(1k) + BMM). These scaffold compositions were compared against each other and against ChronOS (Synthes USA, West Chester, PA, USA), a clinically used bone graft substitute (BGS), which served as the positive control in our experimental design. This BGS is composed of poly(lactide co-ε-caprolactone) and beta-tricalcium phosphate. We used the established rabbit calvaria critical-sized defect model to determine bone regeneration within the defect for each of the three scaffold compositions. New bone formation was determined after 2, 4, 6, 8 and 12 weeks by micro-computerized tomography (μCT) and histology. The experimental tyrosine-derived polycarbonate, enhanced with dicalcium phosphate dihydrate, E1001(1k) + CP, supported significant bone formation within the defects and was superior to the same scaffold containing a mix of BMM, E1001(1k) + BMM. The comparison with the commercially available BGS was complicated by the large variability in bone formation observed for the laboratory preparations of E1001(1k) scaffolds. At all time points, there was a trend for E1001(1k) + CP to be superior to the commercial BGS. However, only at the 6-week time point did this trend reach statistical significance. Detailed analysis of the μCT data suggested an increase in bone formation from 2 through 12 weeks in implant sites treated with E1001(1k) + CP. At 2 and 4 weeks post-implantation, bone formation occurred at the interface where the E1001(1k) + CP scaffold was in contact with the bone borders of the implant site. Thereafter, during weeks 6, 8 and 12 bone formation progressed throughout the E1001(1k) + CP test implants. This trend was not observed with E1001(1k) + BMM scaffolds or the clinically used BGS. Our results suggest that E1001(1k) + CP should be tested further for osteoregenerative applications.

Indexed as

bone regenerationcalcium phosphatedicalcium phosphate dihydraterabbit calvarial critical size defect modeltyrosine-derived polycarbonate

Identifiers

PMID26813289
PMCPMC4669025
OpenAlexW2074023354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.