Evidence map›Paper›PMID 26813208›Full record

Trial reportJAMA2016

Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial.

Bo L Chawes, Klaus Bønnelykke, Jakob Stokholm, Nadja H Vissing, Elín Bjarnadóttir, Ann-Marie M Schoos, Helene M Wolsk, Tine Marie Pedersen, Rebecca K Vinding, Sunna Thorsteinsdóttir and 6 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in JAMA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 174 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 19 pooled it
37.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00856947 phase1active not recruitingnot on this map

Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood: An Interventional Trial in the ABC (Asthma Begins in Childhood) Cohort

TypeinterventionalSponsorCopenhagen Studies on Asthma in ChildhoodRan2009 to 2027Enrolled600ConditionsAsthmaArmsCholecalciferol D3, Placebo tablet
NCT03229317 completednot on this mapstarted 2018, after this paper: background citation

Respiratory Outcome According to Early Maternal Vitamin D Status During Pregnancy in Children Aged 5 to 6 Years Old

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2018 to 2020Enrolled142ConditionsAsthma in ChildrenArmsPlethysmography
3 · Its place in the literature

Who cites it

174 citing papers in PubMed, 19 syntheses or guidelines pooled it, 328 citations in OpenAlex.

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  8. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024
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  14. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
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  15. Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
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  20. Trial

114 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Bo L ChawesCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Jakob StokholmCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark2Department of Pediatrics, Naestved Hospital, Naestved, Denmark.
Nadja H VissingCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Elín BjarnadóttirCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark2Department of Pediatrics, Naestved Hospital, Naestved, Denmark.
Ann-Marie M SchoosCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Helene M WolskCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Tine Marie PedersenCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark2Department of Pediatrics, Naestved Hospital, Naestved, Denmark.
Rebecca K VindingCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark2Department of Pediatrics, Naestved Hospital, Naestved, Denmark.
Sunna ThorsteinsdóttirCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Lambang AriantoCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Henrik W HallasCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Lene HeickendorffDepartment of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Susanne BrixCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Morten A RasmussenCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark5Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Gentofte Hospital · DKUniversity of Copenhagen · DKCopenhagen Prospective Studies on Asthma in Childhood · DKNæstved Sygehus · DKAarhus University Hospital · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceObservational studies have suggested that increased dietary vitamin D intake during pregnancy may protect against wheezing in the offspring, but the preventive effect of vitamin D supplementation to pregnant women is unknown.

objectiveTo determine whether supplementation of vitamin D3 during the third trimester of pregnancy reduces the risk of persistent wheeze in the offspring. DESIGN, SETTING, AND

participantsA double-blind, single-center, randomized clinical trial conducted within the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort. Enrollment began March 2009 with a goal of 708 participants, but due to delayed ethical approval, only 623 women were recruited at 24 weeks of pregnancy. Follow-up of the children (N = 581) was completed when the youngest child reached age 3 years in March 2014.

interventionsVitamin D3 (2400 IU/d; n = 315) or matching placebo tablets (n = 308) from pregnancy week 24 to 1 week postpartum. All women received 400 IU/d of vitamin D3 as part of usual pregnancy care. MAIN OUTCOMES AND MEASURES: Age at onset of persistent wheeze in the first 3 years of life. Secondary outcomes included number of episodes of troublesome lung symptoms, asthma, respiratory tract infections, and neonatal airway immunology. Adverse events were assessed.

resultsOf the 581 children, persistent wheeze was diagnosed during the first 3 years of life in 47 children (16%) in the vitamin D3 group and 57 children (20%) in the control group. Vitamin D3 supplementation was not associated with the risk of persistent wheeze, but the number of episodes of troublesome lung symptoms was reduced, and the airway immune profile was up-regulated (principal component analysis, P = .04). There was no effect on additional end points. Intrauterine death was observed in 1 fetus (<1%) in the vitamin D3 group vs 3 fetuses (1%) in the control group and congenital malformations in 17 neonates (5%) in the vitamin D3 group vs 23 neonates (8%) in the control group. [table: see text]. CONCLUSIONS AND RELEVANCE: The use of 2800 IU/d of vitamin D3 during the third trimester of pregnancy compared with 400 IU/d did not result in a statistically significant reduced risk of persistent wheeze in the offspring through age 3 years. However, interpretation of the study is limited by a wide CI that includes a clinically important protective effect.

trial registrationclinicaltrials.gov Identifier: NCT00856947.

Indexed as

Respiratory SoundsAdultAsthmaChild, PreschoolCholecalciferolDouble-Blind MethodFemaleHumansInfantInfant, NewbornPregnancyPregnancy Trimester, ThirdVitamin DVitamins25-hydroxyvitamin DCholecalciferolVitamin DVitamins

Identifiers

PMID26813208
OpenAlexW2263094600

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.