Evidence map›Paper›PMID 26813006›Full record

ArticleRegenerative biomaterials2015

Distinctive effects of CD34- and CD133-specific antibody-coated stents on re-endothelialization and in-stent restenosis at the early phase of vascular injury.

Xue Wu, Tieying Yin, Jie Tian, Chaojun Tang, Junli Huang, Yinping Zhao, Xiaojuan Zhang, Xiaoyan Deng, Yubo Fan, Donghong Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Applying Principles of Regenerative Medicine to Vascular Stent Development.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. [Endothelial injury and its repair strategies after intravascular stents implantation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xue WuKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Tieying YinKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Jie TianKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Chaojun TangKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Junli HuangKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Yinping ZhaoKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Xiaojuan ZhangKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Xiaoyan DengKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Yubo FanKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Donghong YuKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.
Guixue WangKey Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing Engineering Laboratory in Vascular Implants, Bioengineering College, Chongqing University, No. 174 Shazhengjie, Shapingba, Chongqing 400044, China, School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, HaiDian District, Beijing 100191, China and Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Fredrik Bajers Vej 7, Building H, 9220, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is not clear what effects of CD34- and CD133-specific antibody-coated stents have on re-endothelialization and in-stent restenosis (ISR) at the early phase of vascular injury. This study aims at determining the capabilities of different coatings on stents (e.g. gelatin, anti-CD133 and anti-CD34 antibodies) to promote adhesion and proliferation of endothelial progenitor cells (EPCs). The in vitro study revealed that the adhesion force enabled the EPCs coated on glass slides to withstand flow-induced shear stress, so that allowing for the growth of the cells on the slides for 48 h. The in vivo experiment using a rabbit model in which the coated stents with different substrates were implanted showed that anti-CD34 and anti-CD133 antibody-coated stents markedly reduced the intima area and restenosis than bare mental stents (BMS) and gelatin-coated stents. Compared with the anti-CD34 antibody-coated stents, the time of cells adhesion was longer and earlier present in the anti-CD133 antibody-coated stents and anti-CD133 antibody-coated stents have superiority in re-endothelialization and inhibition of ISR. In conclusion, this study demonstrated that anti-CD133 antibody as a stent coating for capturing EPCs is better than anti-CD34 antibody in promoting endothelialization and reducing ISR.

Indexed as

CD133CD34endothelial progenitor cellsre-endothelializationstent

Identifiers

PMID26813006
PMCPMC4669017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.